Results 21 to 30 of about 10,819 (208)
Dose-dependent phosphorylation and activation of Hh pathway transcription factors
Life Science Alliance, 2022 The Hh gradient is translated into a phosphorylation gradient of Ci/Gli at multiple Fu/CK1 phosphorylation sites, which progressively increases Ci A /Gli A activity by gradually alleviating Sufu-mediated inhibition.
Mengmeng Zhou +4 more
doaj +1 more source
Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis
Molecular & Cellular Oncology, 2020 How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of ...
Miharu Maeda, Yukie Komatsu, Kota Saito
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets.
Yumeng Zhang +7 more
doaj +1 more source
Functions and regulation of the serine/threonine protein kinase CK1 family:moving beyond promiscuity [PDF]
, 2020 Regarded as constitutively active enzymes, known to participate in many, diverse biological processes, the intracellular regulation bestowed on the CK1 family of serine/threonine protein kinases is critically important, yet poorly understood.
Fulcher, Luke J., Sapkota, Gopal P.
core +1 more source
Journal of Fungi, 2022 Like many hemibiotrophic plant pathogens, the root-infecting vascular wilt fungus Fusarium oxysporum induces an increase in the pH of the surrounding host tissue.
Melani Mariscal +4 more
doaj +1 more source
Coordinated Action of CK1 Isoforms in Canonical Wnt Signaling [PDF]
Molecular and Cellular Biology, 2011 Activation of the Wnt pathway promotes the progressive phosphorylation of coreceptor LRP5/6 (low-density lipoprotein receptor-related proteins 5 and 6), creating a phosphorylated motif that inhibits glycogen synthase kinase 3β (GSK-3β), which in turn stabilizes β-catenin, increasing the transcription of β-catenin target genes.
Beatriz, Del Valle-Pérez +4 more
openaire +2 more sources
The APC/C and CK1 in the developing brain
Oncotarget, 2015 Casein Kinase 1δ (CK1δ) is a serione/threonine kinase required for cell cycle progression, circadian rhythm, vesicle trafficking, and neurite outgrowth [1]. CK1δ is also a therapeutic target in various cancers, Alzheimer's disease, alcoholism, and sleep disorders [1].
Clara, Penas +2 more
openaire +2 more sources
Structure–function study of a novel inhibitor of the casein kinase 1 family in Arabidopsis thaliana
Plant Direct, 2019 Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase family among eukaryotes. Studies in non‐plants have shown CK1‐dependent divergent biological processes, but the collective knowledge regarding the biological roles of plant CK1 lags far ...
Ami N. Saito +6 more
doaj +1 more source
Role of CK1 in GSK3β-mediated phosphorylation and degradation of Snail [PDF]
Oncogene, 2010 The epithelial to mesenchymal transition (EMT) that occurs during embryonic development has begun to attract attention as a potential mechanism for tumor cell metastasis. Snail is a well-known Zn-finger transcription factor that promotes EMT by repressing E-cadherin expression.
Y, Xu +9 more
openaire +3 more sources
CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes [PDF]
Cancers, 2022 Protein kinases of the Casein Kinase 1 family play a vital role in the regulation of numerous cellular processes. Apart from functions associated with regulation of proliferation, differentiation, or apoptosis, localization of several Casein Kinase 1 isoforms to the centrosome and microtubule asters also implicates regulatory functions in microtubule ...
Aileen Roth +5 more
openaire +2 more sources