Results 1 to 10 of about 4,901 (129)

Targeting Casein Kinase 1 (CK1) in Hematological Cancers [PDF]

International Journal of Molecular Sciences, 2020
The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. Among those, the most important are the functions of CK1s in the regulation of Wnt
Pavlina Janovska, Emmanuel Normant, Vítězslav Bryja   +2 more
exaly   +5 more sources

Alleviation of Behavioral Hypersensitivity in Mouse Models of Inflammatory Pain with Two Structurally Different Casein Kinase 1 (CK1) Inhibitors [PDF]

Molecular Pain, 2014
Background: The phylogenetically highly conserved CK1 protein kinases consisting of at least seven isoforms form a distinct family within the eukaryotic protein kinases.
Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara, Atsuro Miyata   +9 more
doaj   +4 more sources

Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway. [PDF]

Ann Transl Med, 2021
Glioma is a type of tumor that usually occurs in the adult central nervous system. Protein kinases have become important targets for oncotherapy since they are closely correlated with signal transduction. The role of the casein kinase 1 (CK1) gene in glioma remains to be fully elucidated.The mRNA and protein expression of CK1 were analyzed by Realtime ...
Gao HS, Lin SY, Han X, Xu HZ, Gao YL, Qin ZY.   +5 more
europepmc   +4 more sources

Optimal sequences for non-phosphate-directed phoshorylation by protein kinase CK1 (casein kinase-1) - a re-evaluation [PDF]

FEBS Journal, 1999
A variety of synthetic peptides derived from either the inhibitor‐2 (I‐2) phosphoacceptor sites or the optimal sequences selected in an oriented peptide library have been compared for their susceptibility to phosphorylation by protein kinase CK1 (also termed casein kinase‐1).
Oriano Marin, Flavio Meggio, Catherine C Allende   +2 more
exaly   +3 more sources

Casein kinase I isoforms contribute to platelet activation and thrombogenesis via RIPK3–MLKL signaling [PDF]

Communications Biology
Platelets are small, enucleate blood cells having life span of 10-12 days that play fundamental role in hemostasis and thrombosis. Casein Kinase 1 (CK1) is a serine/threonine-specific protein kinase that governs multiple cellular processes including ...
Vipin Singh, Mohammad Ekhlak, Susheel N. Chaurasia, Debabrata Dash   +3 more
doaj   +2 more sources

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. [PDF]

Proc Natl Acad Sci U S A, 2010
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In mammals, mutations in casein kinase 1 (CK1) ε or δ can alter the circadian period, but the particular functions of the WT isoforms within the pacemaker remain unclear.
Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS.   +16 more
europepmc   +4 more sources

Molecular genetic characterization of CASEIN KINASE 1-LIKE 12 in Arabidopsis [PDF]

Plant Signaling & Behavior
The CASEIN KINASE 1 (CK1) family plays diverse roles in the development, physiology, and disease in eukaryotes. In Arabidopsis thaliana, the CASEIN KINASE 1-LIKE (CKL) family has 13 members, but to date, the roles of these kinases remain largely unclear.
Adam Seluzicki, Annemarie E. Branks, Sowmya Poosapati, Joanne Chory   +3 more
doaj   +2 more sources

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies.
Ondrej Benek, Lukas Hroch, Laura Aitken, Frank Gunn-Moore, Lucie Vinklarova, Kamil Kuca, Daniel I. Perez, Concepcion Perez, Ana Martinez, Zdenek Fisar, Kamil Musilek   +10 more
doaj   +2 more sources

Interaction of casein kinase 1 delta (CK1δ) with the light chain LC2 of microtubule associated protein 1A (MAP1A)

Biochimica Et Biophysica Acta - Molecular Cell Research, 2005
CK1delta, a member of the casein kinase 1 family of serine/threonine specific kinases, has been shown to be involved in the regulation of microtubule dynamics. We have now identified a 176 aa fragment of the light chain LC2 of MAP1A (termed LC2-P16) specifically interacting with CK1delta. Two CK1delta interacting domains of LC2 were identified, located
Zhenyu Xiao, Mathias Wittau, Uwe Knippschild   +2 more
exaly   +3 more sources

Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. [PDF]

PLoS ONE, 2017
Circadian rhythms are intrinsic ~24 hour cycles that regulate diverse aspects of physiology, and in turn are regulated by interactions with the external environment.
Gracie Wee Ling Eng, Edison, David M Virshup   +2 more
doaj   +3 more sources