Results 31 to 40 of about 5,109 (176)

Identification of a secreted casein kinase 1 in Leishmania donovani: effect of protein over expression on parasite growth and virulence. [PDF]

PLoS ONE, 2013
Casein kinase 1 (CK1) plays an important role in eukaryotic signaling pathways, and their substrates include key regulatory proteins involved in cell differentiation, proliferation and chromosome segregation.
Mary Dan-Goor, Abedelmajeed Nasereddin, Hanan Jaber, Charles L Jaffe   +3 more
doaj   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease. [PDF]

Glia
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Abhyankar SD, Xiao Y, Mahajan N, Luo Q, Cummins TR, Oblak AL, Lamb BT, Corson TW, Bhatwadekar AD.   +8 more
europepmc   +2 more sources

Analysis of the Ubiquitination and Phosphorylation of Vangl Proteins

Bio-Protocol, 2022
The core planar cell polarity (PCP) protein Vang/Vangl, including Vangl1 and Vangl2 in vertebrates, is indispensable during development. Our previous studies showed that the activity of Vangl is tightly controlled by two important posttranslational ...
Di Feng, Ziwei He, Bo Gao
doaj   +1 more source

Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga [PDF]

, 2013
Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals.
Barrios-Llerena, Martin E, Andrew J Millar, Thierry Le Bihan, Martin E Barrios-Llerena, Martin, Sarah F, Sarah F Martin, John S O'Neill, O'Neill, John S, Le Bihan, Thierry, Matthew Hindle, Millar, Andrew J; id_orcid, Hindle, Matthew, van Ooijen, Gerben, Gerben van Ooijen   +13 more
core   +1 more source

RP1-59D14.5 triggers autophagy and represses tumorigenesis and progression of prostate cancer via activation of the Hippo signaling pathway

Cell Death and Disease, 2022
Prostate cancer (PCa) is one of the major malignant tumors among men worldwide. Long noncoding RNAs (lncRNAs) have been documented as important modulators in human cancers, including PCa.
Bing Zhong, Zexue Zhao, Xi Jiang
doaj   +1 more source

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1. [PDF]

PLoS ONE, 2015
Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology. Plasmodium falciparum encodes a single CK1 isoform, PfCK1, that is expressed at all stages of the parasite's life cycle. We have
Dominique Dorin-Semblat, Claudia Demarta-Gatsi, Romain Hamelin, Florence Armand, Teresa Gil Carvalho, Marc Moniatte, Christian Doerig   +6 more
doaj   +1 more source

PAWS1 controls Wnt signalling through association with casein kinase 1α [PDF]

, 2018
The BMP and Wnt signalling pathways determine axis specification during embryonic development. Our previous work has shown that PAWS1 (also known as FAM83G) interacts with SMAD1 and modulates BMP signalling.
James C Smith, Timothy D Cummins, Cooper, Fay, Vogt, Janis, Sapkota, Gopal P., Joby Varghese, Bozatzi, Polyxeni, Dingwell, Kevin S., Gopal P Sapkota, Kevin S Dingwell, Campbell, David G., Thomas J Macartney, Fay Cooper, Smith, James C., Polyxeni Bozatzi, Janis Vogt, Wu, Kevin Z. L., Gourlay, Robert, Varghese, Joby, David G Campbell, Kevin ZL Wu, Wood, Nicola T., Nicola T Wood, Luke D Hutchinson, Hutchinson, Luke D., Cummins, Timothy D., Macartney, Thomas J., Robert Gourlay   +27 more
core   +1 more source

Structure–function study of a novel inhibitor of the casein kinase 1 family in Arabidopsis thaliana

Plant Direct, 2019
Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase family among eukaryotes. Studies in non‐plants have shown CK1‐dependent divergent biological processes, but the collective knowledge regarding the biological roles of plant CK1 lags far ...
Ami N. Saito, Hiromi Matsuo, Keiko Kuwata, Azusa Ono, Toshinori Kinoshita, Junichiro Yamaguchi, Norihito Nakamichi   +6 more
doaj   +1 more source

Role of casein kinase 1 in the amoeboid migration of B-cell leukemic and lymphoma cells: A quantitative live imaging in the confined environment

Frontiers in Cell and Developmental Biology, 2022
The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression.
Štěpán Čada, Olga Vondálová Blanářová, Kristína Gömoryová, Antónia Mikulová, Petra Bačovská, Nikodém Zezula, Alka Kumari Jadaun, Pavlína Janovská, Hana Plešingerová, Hana Plešingerová, Vítězslav Bryja, Vítězslav Bryja   +11 more
doaj   +1 more source

Differential effects of SUMO1 and SUMO2 on circadian protein PER2 stability and function

Scientific Reports, 2021
Posttranslational modification (PTM) of core circadian clock proteins, including Period2 (PER2), is required for proper circadian regulation. PER2 function is regulated by casein kinase 1 (CK1)-mediated phosphorylation and ubiquitination but little is ...
Ling-Chih Chen, Yung-Lin Hsieh, Grace Y. T. Tan, Tai-Yun Kuo, Yu-Chi Chou, Pang-Hung Hsu, Wendy W. Hwang-Verslues   +6 more
doaj   +1 more source