Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis
Molecular & Cellular Oncology, 2020 How ER exit sites disassemble during mitosis is not well understood. Transport ANd Golgi Organization 1 (TANGO1, also known as MIA3), a cargo receptor originally identified for collagens, acts as a hub for ER exit site disassembly under the control of ...
Miharu Maeda, Yukie Komatsu, Kota Saito
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Fusarium oxysporum Casein Kinase 1, a Negative Regulator of the Plasma Membrane H+-ATPase Pma1, Is Required for Development and Pathogenicity [PDF]
Journal of Fungi, 2022 Like many hemibiotrophic plant pathogens, the root-infecting vascular wilt fungus Fusarium oxysporum induces an increase in the pH of the surrounding host tissue.
Melani Mariscal +4 more
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Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives
Frontiers in Oncology, 2023 Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
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Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway
Antioxidants, 2021 Endometrial cancer incidence increases annually. Several risk factors, including high glucose intake, are associated with endometrial cancer. We investigated whether glucose affects lysine-specific demethylase 1 (LSD1) expression and the responsible ...
Chiao-Yun Lin +8 more
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Casein Kinase 1 Regulates Ethylene Synthesis by Phosphorylating and Promoting the Turnover of ACS5
Cell Reports, 2014 Summary: The casein kinase 1 (CK1) family participates in various cellular processes in eukaryotes, but CK1 function in higher plants remains largely unknown.
Shu-Tang Tan, Hong-Wei Xue
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A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin
Molecules, 2021 Microtubules composed of α/β tubulin heterodimers are an essential part of the cytoskeleton of eukaryotic cells and are widely regarded as targets for cancer chemotherapy.
Jinghong Xian +8 more
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, 2018 Casein kinase 1 (CK1) proteins phosphorylate a broad range of substrate proteins and are involved in many physiological processes such as metabolism, transcription, cell cycle progression, apoptosis, and differentiation. The development and characterization of new potent CK1-specific inhibitors might be of interest for new therapeutical concepts in ...
García Reyes, Balbina
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, 2008 Casein Kinasen 1 spielen eine wichtige Rolle bei einer Vielzahl unterschiedlicher zellulärer Prozesse, wie z.B. DNA-Reparatur, Zellapoptose, Transkription, tageszeitlicher Rhythmus u.s.w. Ihre Aktivitäten müssen daher strikten Kontrollmechanismen unterliegen.
Oltmer, Franziska Gesine
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Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell-intrinsic and microenvironmental mechanisms. [PDF]
HemasphereAbstract Chronic lymphocytic leukemia (CLL) is a consequence of pathological B‐cell accumulation in blood and lymphoid organs. Due to high refractoriness, CLL is still incurable in many cases; therefore, there is an urgent need to develop novel therapeutic options.
Mikulova A +19 more
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Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch
Frontiers in Molecular Biosciences, 2022 Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is ...
Joel C. Francisco +2 more
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