Results 21 to 30 of about 5,109 (176)

Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion

Frontiers in Cellular and Infection Microbiology, 2021
Casein Kinase 1 (CK1) family members are serine/threonine protein kinases that are involved in many biological processes and highly conserved in eukaryotes from protozoan to humans.
Najma Rachidi, Uwe Knippschild, Gerald F. Späth   +2 more
doaj   +1 more source

Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1 γ 3 in WNT signaling [PDF]

Journal of Biological Chemistry, 2021
Abstract The WNT/ β -catenin signaling pathway is evolutionarily conserved and controls normal embryonic development, adult tissue homeostasis and regeneration. Aberrant activation or suppression of WNT signaling contributes to cancer initiation and progression, developmental ...
Megan J. Agajanian, Frances M. Potjewyd, Brittany M. Bowman, Smaranda Solomon, Kyle M. LaPak, Dhaval P. Bhatt, Jeffery L. Smith, Dennis Goldfarb, Alison D. Axtman, Michael B. Major   +9 more
openaire   +3 more sources

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders

Frontiers in Molecular Biosciences, 2022
Casein kinases are involved in a variety of signaling pathways, and also in inflammation, cancer, and neurological diseases. Therefore, they are regarded as potential therapeutic targets for drug design.
Andrea Baier, Ryszard Szyszka
doaj   +1 more source

Post-Translational Modifications in Animal Circadian Clocks. [PDF]

Adv Sci (Weinh)
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Liu X, Zhang Y.
europepmc   +2 more sources

The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton

Scientific Reports, 2022
The casein kinase 1 (CK1) family of serine/threonine protein kinases is involved in diverse cellular events at discrete subcellular compartments. FAM83H acts as a scaffold protein that recruits CK1 to the keratin cytoskeleton or to the nuclear speckles ...
Takahisa Kuga, Naoki Inoue, Kensuke Sometani, Shino Murataka, Minami Saraya, Rina Sugita, Toshinari Mikami, Yasunori Takeda, Masanari Taniguchi, Kentaro Nishida, Nobuyuki Yamagishi   +10 more
doaj   +1 more source

Disordered but rhythmic-the role of intrinsic protein disorder in eukaryotic circadian timing. [PDF]

FEBS Lett
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Usher ET, Pelham JF.
europepmc   +2 more sources

T. cruzi DNA polymerase beta (Tcpolβ) is phosphorylated in vitro by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity.

PLoS Neglected Tropical Diseases, 2021
The unicellular protozoan Trypanosoma cruzi is the causing agent of Chagas disease which affects several millions of people around the world. The components of the cell signaling pathways in this parasite have not been well studied yet, although its ...
Edio Maldonado, Diego A Rojas, Fabiola Urbina, Aldo Solari   +3 more
doaj   +1 more source

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

eLife, 2022
Liquid-liquid phase separation (LLPS) plays important roles in forming cellular membraneless organelles. However, how host factors regulate LLPS of viral proteins during negative-sense RNA (NSR) virus infection is largely unknown.
Xiao-Dong Fang, Qiang Gao, Ying Zang, Ji-Hui Qiao, Dong-Min Gao, Wen-Ya Xu, Ying Wang, Dawei Li, Xian-Bing Wang   +8 more
doaj   +1 more source

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

Molecular Cancer, 2021
Background 3-phosphoinositide-dependent protein kinase-1 (PDK1) acts as a master kinase of protein kinase A, G, and C family (AGC) kinase to predominantly govern cell survival, proliferation, and metabolic homeostasis.
Qiwei Jiang, Nana Zheng, Lang Bu, Xiaomei Zhang, Xiaoling Zhang, Yuanzhong Wu, Yaqing Su, Lei Wang, Xiaomin Zhang, Shancheng Ren, Xiangpeng Dai, Depei Wu, Wei Xie, Wenyi Wei, Yasheng Zhu, Jianping Guo   +15 more
doaj   +1 more source

Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. [PDF]

PLoS ONE, 2014
The ubiquitously expressed serine/threonine specific casein kinase 1 (CK1) family plays important roles in the regulation of various physiological processes.
Martin Stöter, Marc Krüger, George Banting, Doris Henne-Bruns, Uwe Knippschild   +4 more
doaj   +1 more source