Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch [PDF]
Frontiers in Molecular Biosciences, 2022 Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is ...
Joel C. Francisco +2 more
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Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives [PDF]
Frontiers in Oncology, 2023 Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
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Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex. [PDF]
PLoS Genetics, 2023 Oxidative stress response is a fundamental biological process mediated by conserved mechanisms. The identities and functions of some key regulators remain unknown. Here, we report a novel role of C.
Yiman Hu, Zhaofa Xu, Qian Pan, Long Ma
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Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide [PDF]
iScience, 2022 Summary: Casein kinase 1 γ (CK1G) is involved in the regulation of various cellular functions. For instance, the ceramide transport protein (CERT), which delivers ceramide to the Golgi apparatus for the synthesis of sphingomyelin (SM), is inactivated ...
Asako Goto +4 more
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Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion [PDF]
Frontiers in Cell and Developmental Biology, 2020 Autophagy starts with the initiation and nucleation of isolation membranes, which further expand and seal to form autophagosomes. The regulation of isolation membrane closure remains poorly understood.
Yuting Li +8 more
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Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity [PDF]
Journal of VirologyShiftless (SHFL) is a host antiviral factor that inhibits the viral −1 programmed ribosomal frameshifting (−1PRF). How the antiviral activity of SHFL is regulated is not known. Here, we report that the phosphorylation of SHFL by the casein kinase 1 delta
Yongle Wang +3 more
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Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila [PDF]
Frontiers in Physiology, 2022 Circadian clocks are timing devices that rhythmically adjust organism’s behavior, physiology, and metabolism to the 24-h day-night cycle. Eukaryotic circadian clocks rely on several interlocked transcription-translation feedback loops, where protein ...
Nirav Thakkar +8 more
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Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch [PDF]
eLife, 2020 Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the ...
Jonathan M Philpott +9 more
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Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation [PDF]
eLife, 2019 Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie.
Alexander D Fulford +5 more
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Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice [PDF]
Scientific Reports, 2021 Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory.
Heather Mahoney +13 more
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