Results 41 to 50 of about 43,177 (231)

Crystal structure of casein kinase‐1, a phosphate‐directed protein kinase. [PDF]

The EMBO Journal, 1995
The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart ...
R M, Xu, G, Carmel, R M, Sweet, J, Kuret, X, Cheng   +4 more
openaire   +2 more sources

In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease

Saudi Pharmaceutical Journal, 2021
Salvia species have been traditionally used to improve cognition and have been proved to be a potential natural treatment for Alzheimer’s disease. Salvia fruticosa Mill.
Perihan Gürbüz, Alim Hüseyin Dokumacı, Miyase Gözde Gündüz, Concepcion Perez, Fatih Göger, Mehmet Yavuz Paksoy, Mükerrem Betül Yerer, L. Ömür Demirezer   +7 more
doaj   +1 more source

The Role of Casein Kinase 1 in Meiosis

Journal of Down Syndrome & Chromosome Abnormalities, 2016
The casein kinase 1 (CK1) belongs to the serine/threonine protein kinases. CK1 members, which commonly exist in all eukaryotes, are involved in the regulation of many cellular processes linked to cell cycle progression, spindledynamics, and chromosome segregation.
Yue Fang Zhao, Cheng Guang Liang
openaire   +1 more source

Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δ Inhibitors. [PDF]

ACS Med Chem Lett, 2020
Recent studies have highlighted the key role of Casein kinase 1 δ(CK1δ) in the development of several neurodegenerative pathologies, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).
Cescon E, Bolcato G, Federico S, Bissaro M, Valentini A, Ferlin MG, Spalluto G, Sturlese M, Moro S.   +8 more
europepmc   +3 more sources

Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia [PDF]

Blood, 2018
Key PointsCK1 inhibition significantly blocks microenvironmental interactions of CLL cells. CK1 inhibition slows down development of CLL-like disease in the Eμ-TCL1 mouse model.
Pavlina Janovska, Jan Verner, Jiri Kohoutek, Lenka Bryjova, Michaela Gregorova, Marta Dzimkova, Hana Skabrahova, Tomasz Radaszkiewicz, Petra Ovesna, Olga Vondalova Blanarova, Tereza Nemcova, Zuzana Hoferova, Katerina Vasickova, Lucie Smyckova, Alexander Egle, Sarka Pavlova, Lucie Poppova, Karla Plevova, Sarka Pospisilova, Vitezslav Bryja   +19 more
openaire   +2 more sources

The ATP,Mg-dependent protein phosphatase: regulation by casein kinase-1.

, 1987
The free modulator subunit of the ATP,Mg-dependent phosphatase is phosphorylated up to 1 mol per mol by casein kinase-1, up to 1.85 mol per mol after dephosphorylation by the PCSH1 phosphatase, but 10-fold less when purified in the presence of NaF ...
Goris, Jozef, Merlevede, Wilfried, Goris J, PINNA, LORENZO, Vandenheede, Jackie R., Vandenheede JR, Pinna, Lorenzo A., Patrizia Agostinis, Merlevede W., Jackie R. Vandenheede, Jozef Goris, Wilfried Merlevede, Pinna, L.A., Lorenzo A. Pinna, Vandenheede, Jackie, Meggio, F., MEGGIO, FLAVIO, Agostinis P, Flavio Meggio, Agostinis, Patrizia   +19 more
core   +1 more source

Casein Kinase 1 Promotes Synchrony of the Circadian Clock Network [PDF]

Molecular and Cellular Biology, 2014
Casein kinase 1, known as DOUBLETIME (DBT) in Drosophila melanogaster, is a critical component of the circadian clock that phosphorylates and promotes degradation of the PERIOD (PER) protein. However, other functions of DBT in circadian regulation are not clear, in part because severe reduction of dbt causes preadult lethality.
Xiangzhong, Zheng, Mallory, Sowcik, Dechun, Chen, Amita, Sehgal   +3 more
openaire   +2 more sources

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]

, 2011
Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Tatu, Utpal, Yera, H., Yera, Helene, Talabani, Hana, Talabani, H., Dandavate, V., Dandavate, Vrushali, Langsley, Gordon, Tatu, U., Langsley, G., Bourdoncle, P., Meissner, M., Ben Rached, Fathia, Ndjembo-Ezougou, Carinne, Rached, F.B., Chandran, S., Chandran, Syama, Ndjembo-Ezougou, C., Bourdoncle, Pierre, Meissner, Markus   +19 more
core   +1 more source

Casein Kinase 1 Modulator PF-05251749

Archives of Psychiatry Research, 2020
Back to the Future of Psychopharmacology Regular section of the journal focusing on new and potential treatment options in psychiatry.
Vlahović, Darko, Peitl, Vjekoslav
openaire   +4 more sources

Regulation of p53-MDMX Interaction by Casein Kinase 1 Alpha [PDF]

Molecular and Cellular Biology, 2005
MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of MDMX regulation is largely unknown. We found that MDMX binds to the casein kinase 1 alpha isoform (CK1alpha) and is phosphorylated by CK1alpha.
Lihong, Chen, Changgong, Li, Yu, Pan, Jiandong, Chen   +3 more
openaire   +2 more sources