Results 31 to 40 of about 43,177 (231)
Haematologica, 2016 Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpressed
Alice Melão +3 more
doaj +1 more source
Beryllium toxicity. The selective inhibition of casein kinase 1 [PDF]
Biochemical Journal, 1982 1. Cyclic AMP-independent casein kinase 1 in liver cytoplasm and nuclei was inhibited by Be2+ in vitro (Ki 2.5 microM and 29 microM respectively). Casein kinase 2 (phosvitin kinase) and cyclic AMP-dependent protein kinase were unaffected. 2. The inhibition of casein kinase 1 by Be2+ was competitive with respect to the protein substrate; at non ...
B, Cummings +4 more
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Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. [PDF]
PLoS ONE, 2017 Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes. Mice lacking CK1δ have a perinatal lethal phenotype and typically weigh 30% less than their wild type littermates.
Yoshimi Endo Greer +4 more
doaj +1 more source
Neurobiology of Disease, 2015 Background and purpose: Edema formation, inflammation and increased blood–brain barrier permeability contribute to poor outcomes after intracerebral hemorrhage (ICH).
Loretta O. Iniaghe +5 more
doaj +1 more source
Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 1 [PDF]
The FASEB Journal, 2021 Abstract The mineralocorticoid receptor (MR) with its ligand aldosterone (aldo) physiologically regulates electrolyte homeostasis and blood pressure but it can also lead to pathophysiological effects in the cardiovascular system.
Stefanie Ruhs +10 more
openaire +3 more sources
Effects of predicted potential casein kinase 1 phosphorylation sites on DOXA-1 activity.
, 2023 Effects of predicted potential casein kinase 1 phosphorylation sites on DOXA-1 activity.
Qian Pan (77107) +3 more
core +1 more source
Chinese Medical Journal, 2020 . Background. Gastric cancer (GC) is one of the most common malignancies, and intestinal-type GC is the main histopathologic type of GC in China. We previously reported that casein kinase 2 interacting protein 1 (CKIP-1) acts as a candidate tumor ...
Liang Ma +4 more
doaj +1 more source
A monoclinic crystal form of casein kinase 1 δ [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013 Casein kinase 1 δ (CK1δ) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1δ have previously been determined and this article reports the crystallization and structure determination of a new crystal form ...
Nicholas A, Zeringo +4 more
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Versatile casein kinase 1 [PDF]
Plant Signaling & Behavior, 2009 Members of casein kinase 1 (CK1) are evolutionarily conserved eukaryotic protein kinases, which play fundamental roles in various cellular, physiological and developmental processes. One of the key mechanisms by which the activity of these multifunctional CK1 members is controlled appears to be their specific spatiotemporal compartmentalization within ...
openaire +2 more sources
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +1 more source