Results 51 to 60 of about 43,177 (231)

Stimulation of Eryptosis by Caspofungin

Cellular Physiology and Biochemistry, 2016
Background/Aims: The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria.
Thomas Peter, Rosi Bissinger, Florian Lang   +2 more
doaj   +1 more source

Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. [PDF]

PLoS ONE, 2011
Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic.
Desiree H Fong, Bing Xiong, Jiyoung Hwang, Albert M Berghuis   +3 more
doaj   +1 more source

Phosphorylation of the phosphatase modulator subunit (inhibitor-2) by casein kinase-1 Identification of the phosphorylation sites

, 1992
The isolated modulator subunit of the inactive protein phosphatase-1 is phosphorylated in vitro by casein kinase-1 at two different site Ser-86 and Ser-174. The Ser-86 site is a common target for casein kinase-1 and casein kinase-2, but is preferentially
Merlevede, Wilfried, Peter Hendrix, Vandenheede, Jackie R., James, Peter, Pinna, Lorenzo A., Patrizia Agostinis, Marin, Oriano, Marin, O., Oriano Marin, Jackie R. Vandenheede, Wilfried Merlevede, Pinna, L.A., Lorenzo A. Pinna, James, P., Vandenheede, Jackie, Agostinis, Patrizia, Peter James, Hendrix, Peter   +17 more
core   +1 more source

Myotonic dystrophy-related CDC42-binding kinase alpha (MRCKα) mediates methionine- and leucine-stimulated β-casein synthesis in bovine mammary epithelial cells via targeting mTOR

Animal Nutrition
Amino acids (AA), including methionine (Met) and leucine (Leu), stimulate milk synthesis in bovine mammary epithelial cells (BMEC) via activation of protein kinase mechanistic target of rapamycin (mTOR).
Fang Wang, Jürgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu   +5 more
doaj   +1 more source

Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Nicotinamide, the amide form of vitamin B3, is widely used in disease treatments and stem cell applications. However, nicotinamide's impact often cannot be attributed to its nutritional functions.
Ya Meng, Zhili Ren, Faxiang Xu, Xiaoxiao Zhou, Chengcheng Song, Vivien Ya-Fan Wang, Weiwei Liu, Ligong Lu, James A. Thomson, Guokai Chen   +9 more
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

A noncanonical sequence phosphorylated by casein kinase 1 in β-catenin may play a role in casein kinase 1 targeting of important signaling proteins [PDF]

Proceedings of the National Academy of Sciences, 2003
Protein kinase casein kinase 1 (CK1) phosphorylates Ser-45 of β-catenin, “priming” the subsequent phosphorylation by glycogen synthase-3 of residues 41, 37, and 33. This concerted phosphorylation of β-catenin signals its degradation and prevents its function in triggering cell division.
MARIN, ORIANO, BUSTOS VH, CESARO, LUCA, MEGGIO, FLAVIO, PAGANO, MARIO ANGELO PRIMO, ANTONELLI M, ALLENDE CC, PINNA, LORENZO, ALLENDE J.E.   +8 more
openaire   +5 more sources

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Casein Kinase 1 Alpha Associates With the Tau-Bearing Lesions of Inclusion Body Myositis

, 2008
Inclusion body myositis and Alzheimer\u27s disease are age-related disorders characterized in part by the appearance of intracellular lesions composed of filamentous aggregates of the microtubule-associated protein tau.
Mendell, Jerry R., Kuret, Jeff, Kannanayakal, Theresa   +2 more
core   +1 more source

Image11_Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila.PDF

, 2022
Circadian clocks are timing devices that rhythmically adjust organism’s behavior, physiology, and metabolism to the 24-h day-night cycle. Eukaryotic circadian clocks rely on several interlocked transcription-translation feedback loops, where protein ...
Olga Bazalova (14256296), Jan Martinek (8519184), Ralf Stanewsky (264551), Vlastimil Smykal (193852), Astrid Giesecke (8069885), David Dolezel (6953867), Nirav Thakkar (14256293)   +6 more
core   +1 more source