Results 1 to 10 of about 147 (74)

Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon. [PDF]

PLoS ONE, 2009
The Wnt pathway is a key regulator of development and tumorigenesis. Dpr (Dact/Frodo) influences Wnt signaling in part through the interaction of its PDZ-B domain with Dsh's PDZ domain.
Evelyn Teran, Aron D Branscomb, Joni M Seeling   +2 more
doaj   +7 more sources

Drosophila and Vertebrate Casein Kinase Iδ Exhibits Evolutionary Conservation of Circadian Function [PDF]

Genetics, 2009
AbstractMutations lowering the kinase activity of Drosophila Doubletime (DBT) and vertebrate casein kinase Iε/δ (CKIε/δ) produce long-period, short-period, and arrhythmic circadian rhythms. Since most ckI short-period mutants have been isolated in mammals, while the long-period mutants have been found mostly in Drosophila, lowered kinase activity may ...
Jin-Yuan, Fan, Fabian, Preuss, Michael J, Muskus, Edward S, Bjes, Jeffrey L, Price   +4 more
openaire   +3 more sources

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

FEBS Letters, 2001
Casein kinase Iϵ (CKIϵ), a central component of the circadian clock, interacts with and phosphorylates human period protein 1 (hPER1) [Keesler, G.A. et al. (2000) NeuroReport 5, 951–955]. A mutation in CKIϵ causes a shortened circadian period in Syrian Golden hamster. We have now extended our previous studies to show that human casein kinase Iδ (hCKIδ),
Camacho, F., Cilio, M., Guo, Y., Virshup, D.M., Patel, K., Khorkova, O., Styren, S., Morse, B., Yao, Z., Keesler, G.A.   +9 more
openaire   +2 more sources

Dact Gene Expression Profiles Suggest A Role For This Gene Family In Integrating Wnt And Tgf-β Signaling Pathways During Chicken Limb Development

, 2015
Background: Dact gene family encodes multifunctional proteins that are important modulators of Wnt and TGF-β signaling pathways. Given that these pathways coordinate multiple steps of limb development, we investigated the expression pattern of the two ...
Rirsch T., Xavier-Neto J., Da Veiga F.C., Sensiate L.A., Pedrosa A.V., Collares-Buzato C.B., Dietrich S., Sobreira D.R., Joazeiro P.P., Alvares L.E., Schubert F.R., Peterlini D.J.   +11 more
core   +1 more source

Dact Genes Are Chordate Specific Regulators At The Intersection Of Wnt And Tgf-β Signaling Pathways

, 2015
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Background: Dacts are multi-domain adaptor proteins. They have been implicated in Wnt and Tgfβ signaling and serve as a nodal point in regulating many cellular activities.
Dietrich S., Janousek R.G., Sobreira D.R., Alvares L.E., Schubert F.R.   +4 more
core   +1 more source

Inhibition of casein kinase 1δ disrupts translation initiation and exerts potent antilymphoma activity. [PDF]

Blood Adv, 2022
Pal I, Grilo AMS, Gaspary A, Das Sharma S, Scotto L, O'Connor OA, Jovanovic M, Deng C, Berchowitz LE.   +8 more
europepmc   +1 more source

Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A_2A Adenosine Receptor Useful in Neurodegenerative Disorders. [PDF]

Molecules, 2023
Francucci B, Angeloni S, Dal Ben D, Lambertucci C, Ricciutelli M, Spinaci A, Smirnov A, Volpini R, Buccioni M, Marucci G.   +9 more
europepmc   +1 more source

Prognostic value and immunological role of CSNK1D in human cancers. [PDF]

Aging (Albany NY), 2023
Wang J, Hu B, Wang W.
europepmc   +1 more source

Light-Control over Casein Kinase 1δ Activity with Photopharmacology: A Clear Case for Arylazopyrazole-Based Inhibitors. [PDF]

Int J Mol Sci, 2022
Schulte AM, Kolarski D, Sundaram V, Srivastava A, Tama F, Feringa BL, Szymanski W.   +6 more
europepmc   +1 more source

CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m⁶A-dependent manner. [PDF]

Cell Mol Life Sci, 2023
Qi F, Shen W, Wei X, Cheng Y, Xu F, Zheng Y, Li L, Qin C, Li X.   +8 more
europepmc   +1 more source