Effects of sodium chloride on circadian period and temperature compensation of KaiC phosphorylation [PDF]
Scientific ReportsThe circadian clock is an internal timekeeping system that generates ~ 24-h cycles in physiology and behavior, maintaining a remarkably consistent period across physiological conditions and temperature1.
Eugene Kim +3 more
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Cry1 expression during postnatal development is critical for the establishment of normal circadian period [PDF]
Frontiers in Neuroscience, 2023 The mammalian circadian system generates an approximate 24-h rhythm through a complex autoregulatory feedback loop. Four genes, Period1 (Per1), Period2 (Per2), Cryptochrome1 (Cry1), and Cryptochrome2 (Cry2), regulate the negative feedback within this ...
Aaron E. Schirmer +11 more
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Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing [PDF]
eLife, 2019 The Drosophila circadian pacemaker consists of transcriptional feedback loops subjected to post-transcriptional and post-translational regulation. While post-translational regulatory mechanisms have been studied in detail, much less is known about ...
Lauren E Foley +5 more
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Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. [PDF]
PLoS ONE, 2012 Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein ...
Xiaoqin Liu +2 more
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FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora
Nature Communications, 2019 Circadian clocks control daily rhythms of molecular and physiological activities. Here, the authors show that the interaction between proteins FRQ and CK1, rather than FRQ stability, is a major rate-limiting step in circadian period determination in the ...
Xiao Liu +9 more
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Post‐Translational Modifications in Animal Circadian Clocks [PDF]
Advanced ScienceThe circadian clock is a fundamental biological system that synchronizes behavioral and physiological processes such as metabolism and immunity with the 24 h day‐night cycle.
Xianhui Liu, Yong Zhang
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population analysis of the CLOCK rs3749474T-rs4864548A haplotype and its relationship with obesity
Medwave, 2023 It has been suggested that the rs3749474T/rs4864548A haplotype of the CLOCK gene increases the risk of obesity, but the population variability of these alleles and the haplotype is unknown.
Sergio Flores Carrasco +2 more
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Nature Communications, 2022 PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. Surprisingly, the mouse circadian clock can function independent of PER phosphorylation and PER abundance rhythms.
Yang An +8 more
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Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
Cell Communication and Signaling, 2020 Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycle.
Jacqueline F. Pelham +2 more
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mTOR signaling regulates central and peripheral circadian clock function. [PDF]
PLoS Genetics, 2018 The circadian clock coordinates physiology and metabolism. mTOR (mammalian/mechanistic target of rapamycin) is a major intracellular sensor that integrates nutrient and energy status to regulate protein synthesis, metabolism, and cell growth.
Chidambaram Ramanathan +7 more
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