Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 [PDF]
Biomolecules, 2022 The molecular circadian clock is based on a transcriptional/translational feedback loop in which the stability and half-life of circadian proteins is of importance.
Fernando Martin Baidanoff +5 more
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Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock [PDF]
Genes & Development, 2014 The mammalian circadian clock is based on a transcription–translation feedback loop (TTFL) in which CLOCK and BMAL1 proteins act as transcriptional activators of Cryptochrome and Period genes, which encode proteins that repress CLOCK–BMAL1 with a ...
Ye, Rui +5 more
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GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins [PDF]
Cell Reports, 2015 The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta +8 more
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Circadian PERIOD proteins sculpt the mammalian alternative splicing landscape [PDF]
Abstract Mammalian circadian oscillators are driven by a transcription-translation feedback loop where CLOCK:BMAL1 activity is repressed by the PER:CRY complex. While transcriptional regulation by PER is well established, the role of circadian feedback in co- and post- transcriptional processes remains unclear.
L Chikhaoui +9 more
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The Jumonji C Domain-Containing Protein JMJ30 Regulates Period Length in the Arabidopsis Circadian Clock [PDF]
Plant Physiology, 2010 Abstract Histone methylation plays an essential role in regulating chromatin structure and gene expression. Jumonji C (JmjC) domain-containing proteins are generally known as histone demethylases. Circadian clocks regulate a large number of biological processes, and recent studies suggest that chromatin remodeling has evolved as an ...
Sheen X, Lu +6 more
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Decoupling circadian clock protein turnover from circadian period determination [PDF]
Science, 2015 Defining necessary circadian clock elements The circadian clock in organisms as diverse as fungi and humans have a rather similar structure: Timing depends on daily cycles of transcription in circuits in which feedback loops control the timing of oscillations. A critical role has been ascribed to negative elements,
Luis F. Larrondo +4 more
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Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period [PDF]
Frontiers in Neurology, 2016 The core circadian oscillator in mammals is composed of transcription/translation feedback loop, in which cryptochrome (CRY) proteins play critical roles as repressors of their own gene expression. Although post-translational modifications, such as phosphorylation of CRY1, are crucial for circadian rhythm, little is known about how phosphorylated CRY1 ...
Na Liu, Na Liu, Eric Erquan Zhang
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Heme Binding to the Mammalian Circadian Clock Protein Period 2 Is Nonspecific [PDF]
Biochemistry, 2010 The mammalian circadian clock synchronizes physical and metabolic activity with the diurnal cycle through a transcriptional-posttranslational feedback loop. An additional feedback mechanism regulating clock timing has been proposed to involve oscillation in heme availability.
Michael V, Airola +3 more
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Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila [PDF]
The Journal of Neuroscience, 1990 When the protein encoded by the period (per) gene, which influences circadian rhythms in Drosophila melanogaster, was labeled with an anti- per antibody in adult flies sectioned at different times of day, regular fluctuations in the intensity of immunoreactivity were observed in cells of the visual system and central brain. These fluctuations persisted
Zerr, D. M. +3 more
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KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator
Proceedings of the National Academy of Sciences, 2022 The cyanobacterial clock presents a unique opportunity to understand the biochemical basis of circadian rhythms. The core oscillator, composed of the KaiA, KaiB, and KaiC proteins, has been extensively studied, but a complete picture of its connection to the physiology of the cell is lacking.
Kim, Soo Ji +4 more
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