Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2 [PDF]
, 2009 PERIOD proteins are central components of the Drosophila and mammalian circadian clocks. The crystal structure of a Drosophila PERIOD (dPER) fragment comprising two PER-ARNT-SIM (PAS) domains (PAS-A and PAS-B) and two additional C-terminal alpha-helices (
Strauss, Holger M +26 more
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Structure-based design and classifications of small molecules regulating the circadian rhythm period
Scientific Reports, 2021 Circadian rhythm is an important mechanism that controls behavior and biochemical events based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is associated with different diseases such as cancer, mood disorders, and familial ...
Seref Gul +6 more
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Adult Circadian behavior in Drosophila requires developmental expression of cycle, but not period [PDF]
, 2011 Circadian clocks have evolved as internal time keeping mechanisms that allow anticipation of daily environmental changes and organization of a daily program of physiological and behavioral rhythms.
Bonilla Gloribel +21 more
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Proteome analysis of the circadian clock protein PERIOD2 [PDF]
, 2022 Circadian rhythms are a series of endogenous autonomous 24-h oscillations generated by the circadian clock. At the molecular level, the circadian clock is based on a transcription-translation feedback loop, in which BMAL1 and CLOCK transcription factors ...
Yazan, Seyma +11 more
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The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes. [PDF]
PLoS Genetics, 2014 The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression.
Cheng-Kang Chiang +8 more
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Life Science Alliance, 2019 This study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit. Determining
Sandipan Ray +6 more
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Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. [PDF]
PLoS ONE, 2011 Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours.
Isabelle Schmutz +5 more
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A Heteromeric RNA-Binding Protein Is Involved in Maintaining Acrophase and Period of the Circadian Clock [PDF]
Plant Physiology, 2006 Abstract The RNA-binding protein CHLAMY1 from the green alga Chlamydomonas reinhardtii consists of two subunits. One (named C1) contains three lysine homology motifs and the other (named C3) has three RNA recognition motifs. CHLAMY1 binds specifically to uridine-guanine-repeat sequences and its circadian-binding activity is controlled at
Dobromir, Iliev +5 more
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Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE [PDF]
, 2006 The circadian system of Arabidopsis ( Arabidopsis thaliana) includes feedback loops of gene regulation that generate 24-h oscillations. Components of these loops remain to be identified; none of the known components is completely understood, including ...
Gyula, Peter +47 more
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Bio-Protocol, 2017 Circadian rhythms are biological processes displaying an endogenous oscillation with a period of ~24 h. They allow organisms to anticipate and get prepared for the environmental changes caused mainly by the rotation of Earth. Circadian rhythms are driven
Qiang Chen +3 more
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