Results 51 to 60 of about 5,109 (176)
Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth. [PDF]
PLoS ONE, 2012 Protein-protein interactions forming dominant signalling events are providing ever-growing platforms for the development of novel Biologic tools for controlling cell growth.
Anne-Sophie Huart +3 more
doaj +1 more source
Gli Phosphorylation Code in Hedgehog Signal Transduction
Frontiers in Cell and Developmental Biology, 2022 Hedgehog (Hh) family of secreted proteins governs many key processes in embryonic development and adult tissue homeostasis in species ranging from insects to human.
Mengmeng Zhou, Jin Jiang, Jin Jiang
doaj +1 more source
MedComm, Volume 7, Issue 7, July 2026.This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley +1 more source
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +1 more source
iScience, 2022 Summary: Candida albicans is a leading cause of death due to systemic fungal infections. Poor patient outcomes are attributable to the limited number of antifungal classes and the increasing prevalence of drug resistance.
Yunjin Lee +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15
, 1999 p53 is a potent transcription factor which is regulated by sequential multisite phosphorylation and acetylation. In this paper, we identify threonine 18 of p53, a key site in regulating the interaction between p53 and its regulatory partner MDM2, as a ...
Milne, Diane M. +7 more
core +1 more source
Casein Kinase 1 Promotes Initiation of Clathrin-Mediated Endocytosis [PDF]
, 2015 SummaryIn budding yeast, over 60 proteins functioning in at least five modules are recruited to endocytic sites with predictable order and timing. However, how sites of clathrin-mediated endocytosis are initiated and stabilized is not well understood ...
Barnes, Georjana +8 more
core +1 more source
Stem Cell Research & Therapy, 2021 Background Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets.
Yumeng Zhang +7 more
doaj +1 more source
Liver International, Volume 46, Issue 7, July 2026.ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley +1 more source