Results 61 to 70 of about 5,109 (176)

Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER–Golgi traffic and macroautophagy [PDF]

, 2015
ER-derived COPII-coated vesicles are conventionally targeted to the Golgi. However, during cell stress these vesicles also become a membrane source for autophagosomes, distinct organelles that target cellular components for degradation. How the itinerary
Zhang, Jinzhong, Juan Wang, Jinzhong Zhang, Elizabeth Miller, Wang, Juan, Ding, Jingzhen, Serena Cervantes, Miller, Elizabeth; id_orcid, Saralin Davis, Susan Ferro-Novick, Shekar Menon, Ferro-Novick, Susan, Yu Jiang, Davis, Saralin, Jingzhen Ding, Cervantes, Serena, Menon, Shekar, Jiang, Yu   +17 more
core   +1 more source

In silico investigations on curcuminoids from Curcuma longa as positive regulators of the Wnt/β-catenin signaling pathway in wound healing

Egyptian Journal of Medical Human Genetics, 2021
Background Curcuma longa (Turmeric) is a traditionally used herb in wound healing. The efficacy of fresh turmeric paste to heal wounds has already been investigated in multiple ethnobotanical studies.
Riyan Al Islam Reshad, Sayka Alam, Humaira Binte Raihan, Kamrun Nahar Meem, Fatima Rahman, Fardin Zahid, Md. Ikram Rafid, S. M. Obaydur Rahman, Sadman Omit, Md. Hazrat Ali   +9 more
doaj   +1 more source

Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay

Frontiers in Cell and Developmental Biology, 2022
Leishmaniasis is a severe public health problem, caused by the protozoan Leishmania. This parasite has two developmental forms, extracellular promastigote in the insect vector and intracellular amastigote in the mammalian host where it resides inside the
Despina Smirlis, Despina Smirlis, Florent Dingli, Valentin Sabatet, Aileen Roth, Uwe Knippschild, Damarys Loew, Gerald F. Späth, Najma Rachidi   +8 more
doaj   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Casein kinase 1 underlies temperature compensation of circadian rhythms in human red blood cells [PDF]

, 2019
Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic ...
Braun, Gabriella, Henslee, Erin A., Kruchek, Emily, Labeed, Fatima, Kitcatt, Stephen J., O’Neill, John S., Parry, Jack S.W., Beale, Andrew D., von Schantz, Malcolm, Jabr, Rita, Labeed, Fatima H.   +10 more
core   +1 more source

Purine and Pyrrolopyrimidine‐Based Small Molecules as Multitarget Therapeutics

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Purine and pyrrolopyrimidine scaffolds target multiple oncogenic pathways: cyan kinases (VEGFR‐2, Aurora A, JAK2); red epigenetic/chaperone regulators (HDAC6, BRD4, Hsp90); blue efflux and signaling/sensory modulators (MRP1, PDE, TLR, TRPA1); yellow folate‐pathway enzymes (TS, DHFR, GARFTase), defining a dual‐scaffold platform for multi‐target ...
Federica Borghi, Antonio Laus, Claudia Sorbi, Giulio Rastelli   +3 more
wiley   +1 more source

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi [PDF]

, 2002
The cDNAs for two casein kinase 1 (CK1) homologues, TcCK1.1 and TcCK1.2, have been isolated from Trypanosoma cruzi. Both isoforms showed strong identity with other known CK1s.
Castanys, Santiago, Torres, Cristina, Repetto Scaramelli, Yolanda, Pino, Laura, Spadafora, Carmenza, Morello Casté, Antonio, Robello, Carlos, Gamarro, Francisco   +7 more
core   +1 more source

Phosphorylation-dependent suppression of SERRATE balances miRNA metabolism in planta

Cell Reports
Summary: MicroRNAs (miRNAs) play crucial regulatory roles in multiple developmental processes of animals and plants. Serrate (SE) is essential for miRNA processing and RNA metabolism; however, post-translational modification of SE remains largely ...
Lingli Zheng, Hongwei Xue
doaj   +1 more source

The Role of HUWE1 on Mouse Neural Cell Proliferation and Zebrafish Neurodevelopment

Medicine Bulletin, Volume 2, Issue 3, Page 268-279, June 2026.
ABSTRACT The HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 (HUWE1) gene is located on the X chromosome and has been implicated in neurodevelopmental disorders. However, the mechanisms by which HUWE1 dosage affects nervous system development remain poorly understood. In this study, we demonstrate that HUWE1 overexpression suppresses
Haojuan Wu, Gan Shen, Xueguang Zhang, Xiang Wang, Tiechao Ruan, Chuan Jiang, Yunchuan Tian, Xinyao Tang, Jun Ma, Wenming Xu, Ying Shen   +10 more
wiley   +1 more source

Biochemistry of hypoxia: Refulation of hypoxia inducible factor HIF-1α by casein kinase 1, CK1

, 2010
Hypoxia inducible factor 1, HIF-1, is a heterodimeric transcription factor regulating the cellular response to hypoxia and implicated in many pathological conditions including cancer, ischemia and inflammation. Its inducible subunit, HIF-1α is controlled
Καλούση, Αλκμήνη, Kalousi, Alkmini   +1 more
core   +1 more source