Results 81 to 90 of about 5,109 (176)

Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis

, 2015
SummaryIn meiosis, cohesin is required for sister chromatid cohesion, as well as meiotic chromosome axis assembly and recombination. However, mechanisms underlying the multifunctional nature of cohesin remain elusive.
Watanabe, Yoshinori, Yoshinori Watanabe (8449269), Takashi Sakuno (16039346), Sakuno, Takeshi   +3 more
core   +2 more sources

CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.

PLoS ONE, 2021
Tamoxifen (TAM) is a selective estrogen receptor modulator used for breast cancer patients. Prolonged use of tamoxifen is not recommended for some patients.
Anh Thu Nguyen Hoang, Kwang-Lae Hoe, Sook-Jeong Lee   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, Volume 600, Issue 6, Page 910-938, March 2026.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

PAWS1 controls Wnt signalling through association with casein kinase 1α

, 2020
The BMP and Wnt signalling pathways determine axis specification during embryonic development. Our previous work has shown that PAWS1 (also known as FAM83G) interacts with SMAD1 and modulates BMP signalling.
Robert Gourlay (155277), Fay Cooper (5627117), James C Smith (8273085), Kevin ZL Wu (8318901), Kevin S Dingwell (9071600), Joby Varghese (5627114), David G Campbell (9071606), Luke D Hutchinson (8361993), Gopal P Sapkota (8318916), Nicola T Wood (8318910), Polyxeni Bozatzi (3223929), Janis Vogt (1340304), Timothy D Cummins (9071603), Thomas J Macartney (8318907)   +13 more
core  

Illustration of Wnt/β-catenin signaling.

, 2016
(A) In the absence of an external WNT stimulus β-catenin (referred to by its official gene name CTNNB1 in the figure) is continuously degraded by a ‘destruction complex’ consisting of AXIN1, adenomatous polyposis coli (APC), casein kinase 1 (CK1) and ...
Annika Jacobsen (2806927), Jaap Heringa (9911), K. Anton Feenstra (67029), Folkert Verkaar (120645), Nika Heijmans (2806930), Renée van Amerongen (2806933), Martine J. Smit (120656)   +6 more
core   +1 more source

Human Embryonic Stem Cell-derived Cardiomyocytes with Ischemia Resistant Gap Junctions

, 2020
Ischemic heart disease remains the number one killer worldwide, and no therapies are aimed at restoring lost muscle within patients’ hearts. Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) demonstrate engraftment and mediate beneficial ...
Jargstorf, Joseph
core   +1 more source

Changes in tau phosphorylation in hibernating rodents

, 2013
Tau is a cytoskeletal protein present mainly in the neurons of vertebrates. By comparing the sequence of tau molecule among different vertebrates, it was found that the variability of the N-terminal sequence in tau protein is higher than that of the C ...
Jesús Avila, Hernández Pérez, Félix, Félix Hernández, Javier DeFelipe, Esther García, Vega García-Escudero, García, Esther, León-Espinosa, G., Gonzalo León-Espinosa, DeFelipe, Javier, Ávila, Jesús, García-Escudero, Vega   +11 more
core   +1 more source

Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain

Molecular Pain, 2009
Background Neuropathic pain is a complex chronic pain generated by damage to, or pathological changes in the somatosensory nervous system. Characteristic features of neuropathic pain are allodynia, hyperalgesia and spontaneous pain.
Zong Shuqin, Saegusa Hironao, Kouchi Kasumi, Kurihara Takashi, Sakurai Eri, Tanabe Tsutomu   +5 more
doaj   +1 more source

Schematic drawing of canonical Wnt signaling and GSK3β inhibitors.

, 2019
(A) Inactive canonical Wnt signaling: β-CATENIN is recruited into a cytoplasmic complex with AXIN, CASEIN KINASE 1 (CK1), ADENOMATOUS POLIPOSIS COLI (APC) and GSK3β that phosphorilates β-CATENIN targeting it for proteasomal degradation.
Maria Borrell-Pages (6861881), Lina Badimon (68983), Laura Casaní (3827662), Sandra Camino-Lopez (6861875), Oriol Juan-Babot (6861878)   +4 more
core   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source