Results 101 to 110 of about 5,109 (176)

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

, 2000
Background: Chemical inhibitors of cyclin-dependent kinases (CDKs) have great therapeutic potential against various proliferative and neurodegenerative disorders.
E Damiens, Schultz, P., Dubremetz, J.-F., Gray, N, Knockaert, M., Fergusson, D., Chang, Y.-T., Doerig, C., Y-T Chang, Mottram, J, Meijer, Laurent, Grant, K, Grant, K., K Le Roch, Fergusson, D, M Knockaert, Dubremetz, JF, M Soete, Gray, N., Meijer, L, Le Roch, K, Knockaert, M, Soete, M., Grellier, P, PG Schultz, Grellier, P., C Doerig, Damiens, E, Soete, M, Damiens, E., K Grant, J-F Dubremetz, Chang, Y-T, Dubremetz, J. F., P Grellier, Knockaert, Marie, Schultz, P. G., L Meijer, Fergusson, David, Schultz, PG, Chang, Young-Tae, Meijer, L., Grant, Karen M., N Gray, Mottram, Jeremy C., D Fergusson, J Mottram, Dubremetz, J-F, Chang, Y. T., Mottram, J., Doerig, C, Le Roch, K.   +51 more
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Chronic cadmium exposure aggravates malignant phenotypes of nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway via hypermethylation of the casein kinase 1α promoter

Cancer Management and Research, 2018
Lin Peng,1,2 Yi-Teng Huang,3 Fan Zhang,4 Jiong-Yu Chen,4 Xia Huo5 1Clinical Laboratory, Cancer Hospital of Shantou University Medical College, Shantou 515041, People’s Republic of China; 2Laboratory of Environmental Medicine and Developmental ...
Peng L, Huang YT, Zhang F, Chen JY, Huo X   +4 more
doaj  

Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the malaria parasite, Plasmodium falciparum - Stage-specific expression of the gene

, 1997
The cDNA for casein kinase 1 (CK1) of Plasmodium falciparum was cloned, sequenced, and expressed in bacteria, The single major open reading frame of the 1,2-kilobase pair cDNA coded for a 324-amino acid polypeptide of similar to 37 kDa, the predicted ...
Taylor, Russell E., Barik, Sailen, Chakrabarti, Debopam   +2 more
core   +2 more sources

Protein kinase CK1 interacts with and phosphorylates RanBPM in vitro

, 2020
Members of the casein kinase 1 (CK1) family of serine/threonine kinases are highly conserved from yeast to mammals and are involved in the regulation of various cellular processes.
Doris Henne-Bruns, Joachim Bischof, Balbina García-Reyes, Sonja Wolff, Uwe Knippschild   +4 more
core  

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway

, 2014
Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/β-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular ...
Šedová, Kateřina, Dale, Trevor C, Dhople, Vishnu M., Ganji, Ranjani S, Dale, Trevor C., Korswagen, Hendrik C, Zdráhal, Zbyněk, de Groot, Reinoud E. A., Korswagen, Hendrik C., Bernatik, Ondrej, Bryja, Vitezslav, Dhople, Vishnu M, Ganji, Ranjani S., Lloyd-Lewis, Bethan, de Groot, Reinoud E A, Seipel, Katja   +15 more
core   +1 more source

Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3β and casein kinase 1 kinases

, 2009
In the present study, we report that ubiquitin-mediated degradation of dMyc, the Drosophila homologue of the human c-myc proto-oncogene, is regulated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase kinase 3β ...
Jiang J., Serras F., Parisi F., Rivas L., Bellosta P., Riccardo S., Serra A., Lora C., Pelicci P., Saqcena M. K., Galletti M., Wong B., Grifoni D.   +12 more
core   +1 more source

Connexin phosphorylation as a regulatory event linked to gap junction channel assembly

, 2005
Gap junctions, composed of proteins from the connexin family, allow for intercellular communication between cells and are important in development and maintenance of cell homeostasis.
Solan, Joell L., Lampe, Paul D.
core   +1 more source

Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

, 2010
Nuclear factor of activated T cells (NFAT) proteins are a group of Ca 2+ -regulated transcription factors residing in the cytoplasm of resting cells.
Irena Stevanovic, Klaus Rajewsky, Mark S. Sundrud, Anjana Rao, Sergei B. Koralov, Yoshiteru Sasaki, Martin R. Müller, Srimoyee Ghosh   +7 more
core   +1 more source

Phosphorylation By Casein Kinase 1 Regulates Tonicity-induced Osmotic Response Element-binding Protein/tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking

, 2008
The osmotic response element-binding protein (OREBP), also known as tonicity enhancer-binding protein (TonEBP) or NFAT5, is the only known osmo-sensitive transcription factor that mediates cellular adaptations to extracellular hypertonic stress. Although
Wong, CL, Tong, HY, Yates, JR, Chung, SSM, Ko, CB, Yin, Y, Xu, S   +6 more
core   +1 more source

Data Management and Sharing Plan for: Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesis

The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project ...
Willson, Tim
core   +1 more source