Results 91 to 100 of about 5,109 (176)

Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases

, 2013
The invention relates to a family of differently substituted benzothiazoles having an inhibitory activity against the enzyme casein kinase 1 (CK1), as a result of which they are suitable for use in the treatment or prevention of diseases caused by this ...
Pérez, Concepción, Redondo, Miriam, Pérez Fernández, Daniel Ignacio, Gil, Carmen, Martínez Gil, Ana, García Salado, Irene   +5 more
core  

Gilgamesh is required for the maintenance of germline stem cells in Drosophila testis

Scientific Reports, 2017
Emerging evidence supports that stem cells are regulated by both intrinsic and extrinsic mechanisms. However, factors that determine the fate of stem cells remain incompletely understood.
Dongsheng Chen, Xiangxiang Zhu, Lijuan Zhou, Jian Wang, Xiaoqian Tao, Shuang Wang, Fuling Sun, Xianzhao Kan, Zhengqi Han, Yuelin Gu   +9 more
doaj   +1 more source

Novel dihydropteridinone derivatives as potent inhibitors of the understudied human kinases vaccinia-related kinase 1 and casein kinase 1δ/ε

Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases has significantly hampered our understanding of their cellular ...
Ferreira, Marcos A., Urien, Bruno, Takarada, Jéssica Emi, Gileadi, Opher, Couñago, Rafael M., dos Reis, Caio Vinícius, Santiago, André S., Guimarães, Cristiano R. W., Teodoro, Bruno V. M., Nilsson, Ann-Sofie, de Souza Gama, Fernando H., Mueller, Susanne, Dutra, Luiz A., Serafim, Ricardo A. M., Gileadi, Carina, Elkins, Jonathan M., Balourdas, Dimitrios-Ilias, Lemmens, Bennie B. L. G., Knapp, Stefan, Mascarello, Alessandra, Massirer, Katlin B., Azevedo, Hatylas, Hawgood, Michael, Testa Salmazo, Anita P, Almeida, Vitor M., Vasconcelos, Stanley N. S., Cunha, Micael R., Ramos, Priscila Z.   +27 more
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A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε [PDF]

, 2017
Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For a long time CK1 was thought to act independent of modulatory subunits and in a constitutive manner.
Kalbacher, Hubert, Beat Suter, Suter, Beat, Joachim Bischof, Anna Montada, Halekotte, Jakob, Jakob Halekotte, Hubert Kalbacher, Bischof, Joachim, Uwe Knippschild, Peifer, Christian, Ulrich Baumann, Christine Dolde, Knippschild, Uwe, Simon Grüter, Montada, Anna, Dolde, Christine, Christian Peifer, Grüter, Simon, Baumann, Ulrich   +19 more
core   +1 more source

Arabidopsis thaliana MLK3, a Plant-Specific Casein Kinase 1, Negatively Regulates Flowering and Phosphorylates Histone H3 In Vitro

, 2020
Arabidopsis thaliana MUT9-LIKE KINASES (MLKs), a family of the plant-specific casein kinase 1 (CK1), have been implicated collectively in multiple biological processes including flowering.
Zhen Wang, Shangang Jia, Renjie Yu, Huiting Cui, Wenwen Liu, Junmei Kang, Zhihai Wu   +6 more
core   +1 more source

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling

, 2013
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears unregulated.
Korswagen, H.C., Dolde, C., de Groot, R.E., Niehrs, C., Cruciat, C.M., Ohkawara, B., Reinhard, C.   +6 more
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Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds

Molecules, 2019
In this study, we report on the modification of a 3,4-diaryl-isoxazole-based CK1 inhibitor with chiral pyrrolidine scaffolds to develop potent and selective CK1 inhibitors. The pharmacophore of the lead structure was extended towards the ribose pocket of
Andreas Luxenburger, Dorian Schmidt, Chiara Ianes, Christian Pichlo, Marc Krüger, Thorsten von Drathen, Elena Brunstein, Graeme J. Gainsford, Ulrich Baumann, Uwe Knippschild, Christian Peifer   +10 more
doaj   +1 more source

Protein kinase CK1 interacts with and phosphorylates RanBPM in vitro

, 2015
Members of the casein kinase 1 (CK1) family of serine/threonine kinases are highly conserved from yeast to mammals and are involved in the regulation of various cellular processes.
Bischof, Joachim; Department of General and Visceral Surgery Surgery Center University Hospital Ulm Albert-Einstein-Allee 23 89081 Ulm Germany, Henne-Bruns, Doris; Department of General and Visceral Surgery Surgery Center University Hospital Ulm Albert-Einstein-Allee 23 89081 Ulm Germany, Knippschild, Uwe; Department of General and Visceral Surgery Surgery Center University Hospital Ulm Albert-Einstein-Allee 23 89081 Ulm Germany, García-Reyes, Balbina; Department of General and Visceral Surgery Surgery Center University Hospital Ulm Albert-Einstein-Allee 23 89081 Ulm Germany, Wolff, Sonja; Department of General and Visceral Surgery Surgery Center University Hospital Ulm Albert-Einstein-Allee 23 89081 Ulm Germany   +4 more
core   +1 more source

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

Nature Communications
Candida albicans is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications but remain untapped for antifungal ...
Emily Puumala, Meganathan Nandakumar, Bonnie Yiu, Peter J. Stogios, Benjamin G. Strickland, Robert Zarnowski, Xiaoyu Wang, Noelle S. Williams, Alexei Savchenko, David R. Andes, Nicole Robbins, Luke Whitesell, Timothy M. Willson, Leah E. Cowen   +13 more
doaj   +1 more source

G-protein Coupled Receptor Kinase 2 and Murine Circadian Clock Regulation

, 2014
G-protein coupled receptor kinase 2 (GRK2) is a critical component in the regulation of numerous intracellular signaling pathways. However, its contribution in mammalian circadian clock functioning has not been investigated.
Mehta, Neel
core   +1 more source