Results 71 to 80 of about 5,109 (176)

Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes

Annals of Applied Biology, Volume 188, Issue 3, Page 947-961, May 2026.
This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy, Emad Ibrahim, Jan Ripl, Jiban K. Kundu   +3 more
wiley   +1 more source

Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development. [PDF]

PLoS ONE, 2013
Casein kinase I alpha (CK1α) is a member of serine/threonine protein kinase, generally present in all eukaryotes. In mammals, CK1α regulates the transition from interphase to metaphase in mitosis. However, little is known about its role in meiosis.
Lu Wang, Angeleem Lu, Hong-Xia Zhou, Ran Sun, Jie Zhao, Cheng-Jie Zhou, Jiang-Peng Shen, Sha-Na Wu, Cheng-Guang Liang   +8 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

Cell Proliferation, Volume 59, Issue 5, May 2026.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song   +8 more
wiley   +1 more source

KCTD1 suppresses canonical Wnt signaling pathway by enhancing β-catenin degradation. [PDF]

PLoS ONE, 2014
The canonical Wnt signaling pathway controls normal embryonic development, cellular proliferation and growth, and its aberrant activity results in human carcinogenesis.
Xinxin Li, Cheng Chen, Fangmei Wang, Wenhuan Huang, Zhongheng Liang, Yuzhong Xiao, Ke Wei, Zhenxing Wan, Xiang Hu, Shuanglin Xiang, Xiaofeng Ding, Jian Zhang   +11 more
doaj   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

CK1 is required for iLRP5-mediated β-catenin activation.

, 2012
(A) 293 cells were co-transfected with 1 µg TCF-reporter and iLRP5 construct and incubated for 24 hours with indicated concentrations (nM) of MAPK (PD98059 (PD)), PI3K (wortmannin (Wort)), Akt (Akt-i), or casein kinase 1 (CK1-i) inhibitor.
William K. Decker (186080), Jeffrey M. Rosen (148147), Pierre D. McCrea (173521), Shin-Heng Chiou (186075), Dongsu Park (186072), David M. Spencer (186092), Payam Shahi (186071), Julienne L. Carstens (186077), Mamatha Seethammagari (186074), Kyucheol Cho (173509), Michael M. Ittmann (186087), Adam C. Pond (186073)   +11 more
core   +1 more source

Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer’s Disease: A Computational Study

Marine Drugs, 2018
Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing.
Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martinez   +3 more
doaj   +1 more source

Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3‐Induced T Cell Activation in Preclinical Models

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
In OKT3‐treated human PBMCs, Wnt signaling was downregulated, and co‐treatment with the Wnt activator CHIR99021 reduced T cell activation and apoptosis. In humanized mice, transcriptomic profiling revealed upregulation of genes associated with T cell activation, cytokine and ROS production, and apoptosis, with downregulation of canonical Wnt signaling.
Myeongjin Choi, Duhyeon Park, Da‐Hee Lee, Chang Hoon Choi, Minseong Jo, Seo Yule Jeong, Seung Yeon Lim, Daeui Park, Kyoung‐Sik Moon   +8 more
wiley   +1 more source

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ

, 2023
Specific inhibition of a single kinase isoform is a challenging task due to the highly conserved nature of ATP-binding sites. Casein kinase 1 (CK1) δ and ε share 97% sequence identity in their catalytic domains.
Wayne Grant (1960282), Apirat Chaikuad (244322), Stefan Knapp (244328), William R. Roush (361839), James M. Alburger (4611229), Jun Yong Choi (290863), Eugene Chung (4686145), Simon Bayle (15087420), Yoshihiko Noguchi (14241247), Derek R. Duckett (2417371)   +9 more
core   +1 more source