Results 11 to 20 of about 10,819 (208)
Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. [PDF]
PLoS ONE, 2014 The ubiquitously expressed serine/threonine specific casein kinase 1 (CK1) family plays important roles in the regulation of various physiological processes.
Martin Stöter +4 more
doaj +5 more sources
The CK1 gene family: expression patterning in zebrafish development [PDF]
Biological Research, 2007 Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus.
AMELINA ALBORNOZ +8 more
doaj +12 more sources
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε [PDF]
Journal of Cell Science, 2018 ABSTRACT Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner. Recently, DEAD box RNA helicases, in particular DEAD box RNA helicase 3 X-linked (DDX3X), were found to ...
Christine Dolde +9 more
openaire +5 more sources
The protein kinase CK1: Inhibition, activation, and possible allosteric modulation
Frontiers in Molecular Biosciences, 2022 Protein kinases play a vital role in biology and deregulation of kinases is implicated in numerous diseases ranging from cancer to neurodegenerative diseases, making them a major target class for the pharmaceutical industry.
Yashoda Krishna Sunkari +2 more
doaj +3 more sources
Zebrafish as model system for the biological characterization of CK1 inhibitors
Frontiers in Pharmacology, 2023 Introduction: The CK1 family is involved in a variety of physiological processes by regulating different signaling pathways, including the Wnt/β-catenin, the Hedgehog and the p53 signaling pathways. Mutations or dysregulation of kinases in general and of
Laura Meier +9 more
doaj +4 more sources
Characterization of two T. gondii CK1 isoforms
Molecular and Biochemical Parasitology, 2005 Previous affinity chromatography experiments have described the unexpected binding of an isoform of casein kinase I (CK1) from Leishmania mexicana, Trypanosoma cruzi, Plasmodium falciparum and Toxoplasma gondii to an immobilized cyclin-dependent kinase (CDK) inhibitor (purvalanol B). In order to further evaluate CK1 as a potential anti-parasitic target,
R. G., Donald +3 more
openaire +4 more sources
CK1 Is Required for a Mitotic Checkpoint that Delays Cytokinesis [PDF]
Current Biology, 2013 Failure to accurately partition genetic material during cell division causes aneuploidy and drives tumorigenesis. Cell-cycle checkpoints safeguard cells from such catastrophes by impeding cell-cycle progression when mistakes arise. FHA-RING E3 ligases, including human RNF8 and CHFR and fission yeast Dma1, relay checkpoint signals by binding ...
Johnson, Alyssa E. +2 more
openaire +4 more sources
The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms [PDF]
Biochemical Society Transactions, 2018 The eight members of the FAM83 (FAMily with sequence similarity 83) family of poorly characterised proteins are only present in vertebrates and are defined by the presence of the conserved DUF1669 domain of unknown function at their N-termini. The DUF1669 domain consists of a conserved phospholipase D (PLD)-like catalytic motif.
Bozatzi, Polyxeni, Sapkota, Gopal
openaire +4 more sources
Androgenic regulation of protein kinase CK1 in the prostatic cell.
Cellular & molecular biology research, 1995 We examined the androgenic regulation of protein kinase CK1 in rat ventral prostate cytosolic and chromatin fractions. On androgen deprivation, CK1 in both the nuclear and cytoplasmic compartments decreases slowly at a similar rate. Stimulation of regrowth in the prostate does not evoke an early differential modulation in the CK1 because it increased ...
Ahmed K +4 more
openaire +3 more sources
CK1 in Developmental Signaling [PDF]
Current topics in developmental biology, 2017 The casein kinase 1 (CK1) family of serine (Ser)/threonine (Thr) protein kinases participates in a myriad of cellular processes including developmental signaling. Hedgehog (Hh) and Wnt pathways are two major and evolutionarily conserved signaling pathways that control embryonic development and adult tissue homeostasis.
openaire +2 more sources