Results 31 to 40 of about 10,819 (208)

Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

eLife, 2020
Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the ...
Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch   +9 more
doaj   +1 more source

The Effects of Irrigation Methods on Proline- and Osmotic Stress-Related Genes of Grape (Vitis vinifera L.cv. Moldova) in Arid Regions

Guan'gai paishui xuebao, 2021
【Objective】 Metabolic activities and the genes coding them are modulated by soil water, and the aim of this paper is to study how a new irrigation technology - microfiber capillary core infiltration irrigation (MII) -affects soil water content, leaf ...
CHEN Yu, ZHANG Qingtao, YUAN Libing, CEHN Tuo, CHEN Xiaohong   +4 more
doaj   +1 more source

Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor. [PDF]

PLoS ONE, 2014
Human infection caused by the avian influenza A H7N9 virus has a case-fatality rate of over 30%. Systematic study of the pathogenesis of avian H7N9 isolate and effective therapeutic strategies are needed.BALB/c mice were inoculated intranasally with an ...
Can Li, Chuangen Li, Anna J X Zhang, Kelvin K W To, Andrew C Y Lee, Houshun Zhu, Hazel W L Wu, Jasper F W Chan, Honglin Chen, Ivan F N Hung, Lanjuan Li, Kwok-Yung Yuen   +11 more
doaj   +1 more source

Alleviation of Behavioral Hypersensitivity in Mouse Models of Inflammatory Pain with Two Structurally Different Casein Kinase 1 (CK1) Inhibitors

Molecular Pain, 2014
Background: The phylogenetically highly conserved CK1 protein kinases consisting of at least seven isoforms form a distinct family within the eukaryotic protein kinases.
Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara, Atsuro Miyata   +9 more
doaj   +1 more source

FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora [PDF]

Nature Communications, 2019
AbstractCircadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms.
Xiao Liu, Ahai Chen, Angélica Caicedo-Casso, Guofei Cui, Mingjian Du, Qun He, Sookkyung Lim, Hang J. Kim, Christian I. Hong, Yi Liu   +9 more
openaire   +3 more sources

Long period phenotype induced by CK1 overexpression.

, 2013
(A) Free-running period was analysed by bioluminescent imaging in 6 independent transgenic lines overexpressing CK1 in the CCA1-LUC background. Lines were compared against the parent line in identical plate positions.
François-Yves Bouget (237565), Thierry Le Bihan (417076), Martin Barrios-Llerena (437232), Sarah F. Martin (437231), John S. O’Neill (437233), Matthew Hindle (437230), Gerben van Ooijen (437229), Frédéric Sanchez (337649), Andrew J. Millar (235077)   +8 more
core   +1 more source

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies.
Ondrej Benek, Lukas Hroch, Laura Aitken, Frank Gunn-Moore, Lucie Vinklarova, Kamil Kuca, Daniel I. Perez, Concepcion Perez, Ana Martinez, Zdenek Fisar, Kamil Musilek   +10 more
doaj   +1 more source

TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients

Frontiers in Molecular Neuroscience, 2023
IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked.
Loreto Martinez-Gonzalez, Loreto Martinez-Gonzalez, Eva P. Cuevas, Eva P. Cuevas, Carlota Tosat-Bitrián, Carlota Tosat-Bitrián, Vanesa Nozal, Vanesa Nozal, Carmen Gil, Valle Palomo, Valle Palomo, Ángeles Martín-Requero, Ángeles Martín-Requero, Ana Martinez, Ana Martinez   +14 more
doaj   +1 more source

The first armadillo repeat is involved in the recognition and regulation of beta-catenin phosphorylation by protein kinase CK1 [PDF]

, 2006
Multiple phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence.
Bustos, Victor H., PINNA, LORENZO, ALLENDE JE, VENERANDO, ANDREA, Pinna, Lorenzo A., MARIN, ORIANO, BUSTOS VH, FERRARESE, ANNA, Allende, Jorge E.   +8 more
core   +3 more sources

Effects of Bacillus amyloliquefaciens QSB-6 on the Growth of Replanted Apple Trees and the Soil Microbial Environment

Horticulturae, 2022
Apple replant disease (ARD), caused largely by soil-borne fungal pathogens, has seriously hindered the development of the apple industry. The use of antagonistic microorganisms has been confirmed as a low-cost and environmentally friendly means of ...
Yanan Duan, Yifan Zhou, Zhao Li, Xuesen Chen, Chengmiao Yin, Zhiquan Mao   +5 more
doaj   +1 more source