Results 41 to 50 of about 10,819 (208)

Identification of a secreted casein kinase 1 in Leishmania donovani: effect of protein over expression on parasite growth and virulence. [PDF]

PLoS ONE, 2013
Casein kinase 1 (CK1) plays an important role in eukaryotic signaling pathways, and their substrates include key regulatory proteins involved in cell differentiation, proliferation and chromosome segregation.
Mary Dan-Goor, Abedelmajeed Nasereddin, Hanan Jaber, Charles L Jaffe   +3 more
doaj   +1 more source

Changes of Soil Water and Heat Transport and Yield of Tomato (Solanum lycopersicum) in Greenhouses with Micro-Sprinkler Irrigation under Plastic Film

Agronomy, 2022
This study aimed to expound the changes in soil water flow, heat transport, and tomato production under micro-sprinkler irrigation and plastic film (MSPF) conditions. The effects of different irrigation amounts (I1:0.7 Epan; I2:1.0 Epan; and I3:1.2 Epan (
Mingzhi Zhang, Yuan Li, Jianfei Liu, Jingwei Wang, Zhenxing Zhang, Na Xiao   +5 more
doaj   +1 more source

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders

Frontiers in Molecular Biosciences, 2022
Casein kinases are involved in a variety of signaling pathways, and also in inflammation, cancer, and neurological diseases. Therefore, they are regarded as potential therapeutic targets for drug design. Recent studies have highlighted the importance of the casein kinase 1 superfamily as well as protein kinase CK2 in the development of several ...
Andrea Baier, Ryszard Szyszka
openaire   +3 more sources

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

CK1 inhibitor leads to period lengthening.

, 2013
(A–B) Dose–response curves showing free-running period lengthening of CCA1-LUC lines (black line) treated with CK1 inhibitor IC261 (A) or PF-670462 (B). Blue line indicates the period effects of the same range of inhibitors on the CK1 overexpression line
François-Yves Bouget (237565), Thierry Le Bihan (417076), Martin Barrios-Llerena (437232), Sarah F. Martin (437231), John S. O’Neill (437233), Matthew Hindle (437230), Gerben van Ooijen (437229), Frédéric Sanchez (337649), Andrew J. Millar (235077)   +8 more
core   +1 more source

Functional analysis of Casein Kinase 1 in a minimal circadian system.

PLoS ONE, 2013
The Earth's rotation has driven the evolution of cellular circadian clocks to facilitate anticipation of the solar cycle. Some evidence for timekeeping mechanism conserved from early unicellular life through to modern organisms was recently identified ...
Gerben van Ooijen, Matthew Hindle, Sarah F Martin, Martin Barrios-Llerena, Frédéric Sanchez, François-Yves Bouget, John S O'Neill, Thierry Le Bihan, Andrew J Millar   +8 more
doaj   +1 more source

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

eLife, 2022
Liquid-liquid phase separation (LLPS) plays important roles in forming cellular membraneless organelles. However, how host factors regulate LLPS of viral proteins during negative-sense RNA (NSR) virus infection is largely unknown.
Xiao-Dong Fang, Qiang Gao, Ying Zang, Ji-Hui Qiao, Dong-Min Gao, Wen-Ya Xu, Ying Wang, Dawei Li, Xian-Bing Wang   +8 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

PML enhances the regulation of p53 by CK1 in response to DNA damage [PDF]

Oncogene, 2008
In response to stress, p53 is accumulated and activated to induce appropriate growth inhibitory responses. This requires the release of p53 from the constraints of its negative regulators Mdm2 and Mdm4. A key event in this dissociation is the phosphorylation of p53 at threonine residue (Thr18) within the Mdm2/4-binding domain.
O, Alsheich-Bartok, S, Haupt, I, Alkalay-Snir, S, Saito, E, Appella, Y, Haupt   +5 more
openaire   +2 more sources