Results 61 to 70 of about 10,819 (208)
Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.ABSTRACT Photobiomodulation (PBM) has gained recognition as a promising, non‐invasive strategy to enhance the differentiation of adipose‐derived stem cells (ADSCs) into smooth muscle cells (SMCs), particularly when used together with a three‐dimensional (3D) hydrogel culture system.
Christevie Mbuyu +2 more
wiley +1 more source
Substrate displacement of CK1 C-termini regulates kinase specificity
, 2023 Abstract CK1 kinases participate in many signaling pathways; how these enzymes are regulated is therefore of significant biological consequence. CK1s autophosphorylate their C-terminal non-catalytic tails, and eliminating these modifications increases substrate phosphorylation in vitro, suggesting that the ...
Sierra N. Cullati +3 more
openaire +2 more sources
Prosurvival autophagy is regulated by protein kinase CK1 alpha in multiple myeloma [PDF]
Cell Death Discovery, 2019 AbstractMultiple myeloma (MM) is a tumor of plasma cells (PCs). Due to the intense immunoglobulin secretion, PCs are prone to endoplasmic reticulum stress and activate several stress-managing pathways, including autophagy. Indeed, autophagy deregulation is maladaptive for MM cells, resulting in cell death.
Carrino, Marilena +9 more
openaire +3 more sources
O konstytutywnej współzależności wyjaśniania i identyfikowania czynności konwencjonalnych
Ruch Prawniczy, Ekonomiczny i Socjologiczny, 2019 Artykuł dotyczy specyficznej współzależności między identyfikacją a intencjonalnym wyjaśnianiem czynności konwencjonalnych (w szczególności prawnie doniosłych czynności konwencjonalnych).
Olgierd Bogucki
doaj +1 more source
MedComm, Volume 7, Issue 7, July 2026.This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
, 2018 ZEN removal abilities of hydrated sodium calcium aluminosilicate (HSCAS), Lactobacillus rhamnosus GG (LGG), and Bacillus licheniformis CK1 (CK1).
Je-Ruei Liu (619827) +3 more
core +1 more source
Liver International, Volume 46, Issue 7, July 2026.ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley +1 more source
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
Biochemical and cellular characteristics of the four splice variants of protein kinase CK1 α from zebrafish (Danio rerio) [PDF]
, 2002 Protein kinase CK1 (previously known as casein kinase I) conforms to a subgroup of the great protein kinase family found in eukaryotic organisms. The CK1 subgroup of vertebrates contains seven members known as α, β, γ1, γ2, γ3, δ and ε.
Antonelli, Marcelo +3 more
core +1 more source