Results 71 to 80 of about 10,819 (208)

Purine and Pyrrolopyrimidine‐Based Small Molecules as Multitarget Therapeutics

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Purine and pyrrolopyrimidine scaffolds target multiple oncogenic pathways: cyan kinases (VEGFR‐2, Aurora A, JAK2); red epigenetic/chaperone regulators (HDAC6, BRD4, Hsp90); blue efflux and signaling/sensory modulators (MRP1, PDE, TLR, TRPA1); yellow folate‐pathway enzymes (TS, DHFR, GARFTase), defining a dual‐scaffold platform for multi‐target ...
Federica Borghi, Antonio Laus, Claudia Sorbi, Giulio Rastelli   +3 more
wiley   +1 more source

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D) [PDF]

, 2019
International audienceMembers of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human.
Xu, P., Gärtner, F., Ianes, C., Ianes, Chiara, Xu, Pengfei, Bischof, Joachim, Liu, Congxing, Knippschild, U., Bischof, J., Knippschild, Uwe, Burster, Timo, Bakulev, Vasiliy, Burster, T., Gärtner, Fabian, Rachidi, Najma, Bakulev, V., Rachidi, N., Liu, C.   +17 more
core   +1 more source

Effect of feeding hydroponic barley seedlings to lactating ewes on blood biochemical indexes and growth performance of lambs

Frontiers in Veterinary Science
The aim of this study was to investigate the effects of replacing different ratios of basal diets with hydroponically barley seedlings (HBS) on the serum biochemical indexes and growth performance of lambs.
Yan Ma, Tongjun Guo, Tongjun Guo, Zhijun Zhang, Zhijun Zhang, Guzalnur Amat, Guzalnur Amat, Yaxing Jing, Yong Tuo, Liangzhong Hou   +9 more
doaj   +1 more source

Co‐inoculation with Bacillus and exopolysaccharide Cp2‐exopolysaccharides promotes salt stress tolerance and productivity in alfalfa

Grassland Research, Volume 5, Issue 2, Page 119-131, June 2026.
Co‐inoculation with Bacillus and Cp2‐Exopolysaccharides (EPS) promotes salt stress tolerance and productivity in alfalfa. CK1 (control1): distilled water, DN2: Bacillus strain DN2, EPS: Exopolysaccharide, CK2 (control2): 100 mmol·L‐1 NaCl, S: Salt. Abstract Background Alfalfa is one of the most important forage crops in the world, and its performance ...
Rong Huang, Haiyan Chen, Xuemei Liu, Hsiang Tom, Xiaoni Liu, Zhenfen Zhang   +5 more
wiley   +1 more source

Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds

Molecules, 2019
In this study, we report on the modification of a 3,4-diaryl-isoxazole-based CK1 inhibitor with chiral pyrrolidine scaffolds to develop potent and selective CK1 inhibitors. The pharmacophore of the lead structure was extended towards the ribose pocket of
Andreas Luxenburger, Dorian Schmidt, Chiara Ianes, Christian Pichlo, Marc Krüger, Thorsten von Drathen, Elena Brunstein, Graeme J. Gainsford, Ulrich Baumann, Uwe Knippschild, Christian Peifer   +10 more
doaj   +1 more source

Effects of sprouty4 protein on keratinocyte proliferation and differentiation

Pifu-xingbing zhenliaoxue zazhi, 2020
Objective: To explore the effects of sprouty4 (SPRY4) protein on keratinocyte proliferation and differentiation. Methods: Human immortalized keratinocytes (HaCaT) cells were transfected with SPRY4 protein siRNA, and HaCaT cells without transfection ...
Yu-qi HUANG, Li LI, Wei ZHONG, Lei ZHU, Jing-xia LIN, Jiao ZHANG, Yong-feng CHEN   +6 more
doaj   +1 more source

The Role of HUWE1 on Mouse Neural Cell Proliferation and Zebrafish Neurodevelopment

Medicine Bulletin, Volume 2, Issue 3, Page 268-279, June 2026.
ABSTRACT The HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 (HUWE1) gene is located on the X chromosome and has been implicated in neurodevelopmental disorders. However, the mechanisms by which HUWE1 dosage affects nervous system development remain poorly understood. In this study, we demonstrate that HUWE1 overexpression suppresses
Haojuan Wu, Gan Shen, Xueguang Zhang, Xiang Wang, Tiechao Ruan, Chuan Jiang, Yunchuan Tian, Xinyao Tang, Jun Ma, Wenming Xu, Ying Shen   +10 more
wiley   +1 more source

Anti-pathogenic activities of Bacillus licheniformis CK1.

, 2018
Anti-pathogenic activities of Bacillus licheniformis CK1.
Je-Ruei Liu (619827), Tsui-Chun Hsu (5089109), Ping-Jung Yi (5089106), Ting-Yu Lee (2355979)   +3 more
core   +1 more source

配施增效助剂对四川旱地小麦的减氮效应研究

Shuitu Baochi Xuebao, 2023
为探究增效助剂对四川旱地小麦的减氮效应,设置空白对照(CK0)、常规施氮不追肥(CK1,施氮量187.5 kg/hm2)、常规施氮量下底追比6∶4(CK2,施氮量187.5 kg/hm2)、增效助剂拌常规复合肥,减氮20%(jf—20%),减氮30%(jf—30%)、增效助剂螯合脲甲醛减氮20%(jn—20%),减氮30%(jn—30%),减氮40%(jn—40%)、增效助剂螯合脲甲醛肥+卵磷脂有机肥3 000 kg/hm2减氮27%(jny—27%)等9个处理,分析测定不同处理下土壤氮素动态 ...
李俊积, 马海艳, 马宏亮, 雷芳, 邹乔生, 祝婷婷, 杨洪坤, 黄秀兰, 樊高琼   +8 more
doaj  

Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction

Nature Communications, 2022
PERIOD proteins, the core components of the mammalian circadian clock, act as the CK1 scaffold in the negative feedback process. Surprisingly, the mouse circadian clock can function independent of PER phosphorylation and PER abundance rhythms.
Yang An, Baoshi Yuan, Pancheng Xie, Yue Gu, Zhiwei Liu, Tao Wang, Zhihao Li, Ying Xu, Yi Liu   +8 more
doaj   +1 more source