Results 91 to 100 of about 10,819 (208)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, Volume 13, Issue 29, 22 May 2026.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Chemical dissection of the APC repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3 [PDF]

, 2007
A crucial event in machinery controlled by Wnt signaling is the association of beta-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of beta-catenin and requires the multiple phosphorylation of APC at six ...
Bustos, Victor H., PINNA, LORENZO, Antonelli, Marcelo, ALLENDE JE, Ferrarese, Anna, VENERANDO, ANDREA, Pinna, Lorenzo A., MARIN, ORIANO, FERRARESE A, ANTONELLI M, BUSTOS VH, Allende, Jorge E.   +11 more
core   +1 more source

Substrate displacement of CK1 C-termini regulates kinase specificity

Science Advances
CK1 kinases participate in many signaling pathways, and their regulation is of meaningful biological consequence. CK1s autophosphorylate their C-terminal noncatalytic tails, and eliminating these tails increases substrate phosphorylation in vitro, suggesting that the autophosphorylated C-termini act as inhibitory pseudosubstrates ...
Sierra N. Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L. Johnson, Tomer M. Yaron-Barir, Lewis C. Cantley, Kathleen L. Gould   +6 more
openaire   +2 more sources

Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta [PDF]

Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis.
Giampiero Spalluto, Trevisan, Letizia, Colotta, Vittoria, Ilenia Grieco, Calenda, Sara, Spalluto, Giampiero, Varano, Flavia, Spinaci, Andrea, Federico, Stephanie, Erica Vigiani, Rosaria Volpini, Stefano Moro, Volpini, Rosaria, Andrea Spinaci, Volpini Rosaria, Sara Calenda, Vittoria Colotta, Catia Lambertucci, Veronica Salmaso, Lambertucci, Catia, Letizia Trevisan, Daniela Catarzi, Gianluca Novello, Vigiani, Erica, Moro, Stefano, Stephanie Federico, Salmaso, Veronica, Novello, Gianluca, Flavia Varano, Catarzi, Daniela, Grieco, Ilenia   +30 more
core   +1 more source

The single CK1 homolog in O. tauri is diurnally expressed.

, 2013
A rooted phylogenetic tree has been generated from a sequence alignment of the CK1 isoforms in animal species Drosophila melanogaster, human (or mouse), the fungus Neurospora crassa, the moss Physcomitrellapatens, the plant Arabidopsis thaliana, and the ...
François-Yves Bouget (237565), Thierry Le Bihan (417076), Martin Barrios-Llerena (437232), Sarah F. Martin (437231), John S. O’Neill (437233), Matthew Hindle (437230), Gerben van Ooijen (437229), Frédéric Sanchez (337649), Andrew J. Millar (235077)   +8 more
core   +1 more source

Table2_Zebrafish as model system for the biological characterization of CK1 inhibitors.DOCX

, 2023
Introduction: The CK1 family is involved in a variety of physiological processes by regulating different signaling pathways, including the Wnt/β-catenin, the Hedgehog and the p53 signaling pathways. Mutations or dysregulation of kinases in general and of
Stefan Kirschner (16961514), Aileen Roth (11702348), Joana Baier (16961520), Laura Meier (8812061), Steffen Just (2556940), Adrian Gihring (9176495), Clemens Woitaske-Proske (16961517), Christian Peifer (189857), Uwe Knippschild (189859), Bernd Martin Gahr (16961511)   +9 more
core   +1 more source

肺癌患者外周血CK19mRNA和CyFRA21-1水平的相关性研究

Zhongguo shiyan zhenduanxue, 2002
目的　研究肺癌患者外周血细胞角蛋白 1 9（CyFRA2 1 1 ）水平和CK1 9mRNA表达水平的相关性 ,并评价其对肺癌临床诊断的价值。方法　用逆转录多聚酶链反应法 （RT PCR）和酶联免疫吸附法 （ELISA）分别测定 91例肺癌、33例良性肺病患者、50例健康人外周血CK1 9mRNA的表达水平和血清CyFRA2 1 1水平。结果　肺癌组患者CK1 9mRNA阳性率和CyFRA2 1 1水平明显高于良性肺病组 （P
潘锵荣, 张行, 曹江, 陈月兰
doaj  

CK1 family kinases and their role in Wnt signalling [PDF]

, 2017
Wnt signalizace je velmi důležitou drahou pro vývoj a růst buněk. V člověka obsahuje šest proteinů různých funkcí a struktur, kódovaných různými geny. Signalizační kaskáda začíná vazbou molekuly Wnt na receptory cílové buňky.
Horázná, Daniela
core  

Table5_Zebrafish as model system for the biological characterization of CK1 inhibitors.DOCX

, 2023
Introduction: The CK1 family is involved in a variety of physiological processes by regulating different signaling pathways, including the Wnt/β-catenin, the Hedgehog and the p53 signaling pathways. Mutations or dysregulation of kinases in general and of
Stefan Kirschner (16961514), Aileen Roth (11702348), Joana Baier (16961520), Laura Meier (8812061), Steffen Just (2556940), Adrian Gihring (9176495), Clemens Woitaske-Proske (16961517), Christian Peifer (189857), Uwe Knippschild (189859), Bernd Martin Gahr (16961511)   +9 more
core   +1 more source

肺癌患者外周血CK19mRNA和CyFRA21-1水平的相关性研究 附视频

Zhongguo shiyan zhenduanxue, 2002
目的　研究肺癌患者外周血细胞角蛋白 1 9(CyFRA2 1 1 )水平和CK1 9mRNA表达水平的相关性 ,并评价其对肺癌临床诊断的价值。方法　用逆转录多聚酶链反应法 (RT PCR)和酶联免疫吸附法 (ELISA)分别测定 91例肺癌、33例良性肺病患者、50例健康人外周血CK1 9mRNA的表达水平和血清CyFRA2 1 1水平。结果　肺癌组患者CK1 9mRNA阳性率和CyFRA2 1 1水平明显高于良性肺病组 (P
潘锵荣, 张行, 曹江, 陈月兰, 1.浙江大学肿瘤研究所, 2.浙江大学肿瘤研究所, 3.浙江大学肿瘤研究所, 4.浙江大学肿瘤研究所 浙江杭州310009, 5.浙江杭州310009, 6.浙江杭州310009, 7.浙江杭州310009   +10 more
doaj