Results 101 to 110 of about 10,819 (208)
CK1 alpha Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability
, 2009 The ubiquitin ligase murine double minute clone 2 (MDM2) mediates ubiquitination and degradation of the tumor suppressor p53. The activation and stabilization of p53 by contrast is maintained by enzymes catalyzing p53 phosphorylation and acetylation ...
Hupp, Ted R. +3 more
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Image2_Zebrafish as model system for the biological characterization of CK1 inhibitors.TIF
, 2023 Introduction: The CK1 family is involved in a variety of physiological processes by regulating different signaling pathways, including the Wnt/β-catenin, the Hedgehog and the p53 signaling pathways. Mutations or dysregulation of kinases in general and of
Stefan Kirschner (16961514) +9 more
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Exploiting the MDM2-CK1 alpha Protein-Protein Interface to Develop Novel Biologics That Induce UBL-Kinase-Modification and Inhibit Cell Growth [PDF]
, 2012 Protein-protein interactions forming dominant signalling events are providing ever-growing platforms for the development of novel Biologic tools for controlling cell growth.
MacLaine, Nicola J +17 more
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Differential mechanism of action of the CK1$\varepsilon $ inhibitor GSD0054
Journal of Molecular and Clinical Medicine, 2018 In the current study, we explored for the first time, the mechanism of action of the new Casein kinase 1 $\varepsilon$ (CK1$\varepsilon$) selective inhibitor GSD0054. Although GSD0054 behaved as a selective CK1$\varepsilon $ inhibitor in enzymatic assays, we studied whether this inhibitory activity also occurred inside the cells. The effects of GSD0054
José M. Padrón +4 more
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Phosphorylation-dependent suppression of SERRATE balances miRNA metabolism in planta
Cell ReportsSummary: MicroRNAs (miRNAs) play crucial regulatory roles in multiple developmental processes of animals and plants. Serrate (SE) is essential for miRNA processing and RNA metabolism; however, post-translational modification of SE remains largely ...
Lingli Zheng, Hongwei Xue
doaj +1 more source
Toxins, 2016 Zearalenone (ZEA), an estrogenic mycotoxin, is mainly produced by Fusarium fungi. In this study, Bacillus licheniformis CK1 isolated from soil with the capability of degrading ZEA was evaluated for its efficacy in reducing the adverse effects of ZEA in ...
Guanhua Fu +5 more
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Evaluation of Detoxifying Effect of Bacillus licheniformis CK1 on Zearalenone
, 2013 玉米烯酮為黴菌所產生之次級代謝物，為鐮菌屬真菌所產生之黴菌毒素，常見於玉米、小麥、大麥等穀物中。玉米烯酮可能對家畜造成不孕、流產等繁殖性能上的影響，亦具有致癌性、基因毒性、血液毒性或免疫毒性等，對家畜或人體健康造成威脅。研究顯示Bacillus licheniformis CK1在in vitro試驗中可降低培養液中玉米烯酮含量，其機制可能為降解作用及吸附作用。本研究探討B.
王玥淳, Wang, Yue-Chun
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Yield performance and growth characteristics of rice grown in plastic film mulched dryland
浙江大学学报. 农业与生命科学版, 2002 Multi-location experiments were conducted to study the effects of planting rice in plastic film mulched dryland (PFMD) on growth and yield formation in rice.
JIN Qian-yu +2 more
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Vegetable ResearchProtected vegetable production relies on drip irrigation for precise water and fertilizer delivery, which modifies the root zone microenvironment and microbial structure to influence yield and quality.
Qi Chen +6 more
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Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes
, 1997 This work addresses two issues, the use of antisense oligodeoxynucleotides to deplete specific mRNAs in Xenopus oocytes to analyze their functions during development and the role of cytokeratin filaments in cells of the early Xenopus embryo.
Wylie, C (15531626) +4 more
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