Results 111 to 120 of about 4,588 (199)

A Proteolytic Site‐Directed Affinity Label to Inhibit the Human ATP‐Dependent Protease Caseinolytic Complex XP

ChemBioChem, 2020
AbstractHuman caseinolytic protease component X and P (hClpXP) is a heterooligomeric ATP‐dependent protease. The hClpX subunit catalyzes ATP hydrolysis whereas the hClpP subunit catalyzes peptide bond cleavage. In this study, we generated a peptidyl chloromethyl ketone (dansyl‐FAPAL‐CMK) that inhibited the hClpP subunit through alkylation of the ...
Zhou Sha, Sujatha Chilakala, George Crabill, Iteen Cheng, Yan Xu, Jennifer Fishovitz, Irene Lee   +6 more
openaire   +3 more sources

Molecular cloning and biochemical characterization of Xaa-Pro dipeptidyl-peptidase from Streptococcus mutans and its inhibition by anti-human DPP IV drugs

, 2016
Streptococcus mutans harbours an intracellular, human DPP IV-analogous enzyme Xaa-Pro dipeptidyl-peptidase (EC 3.4.14.11). According to previous reports, an extracellular isozyme in S. gordonii and S. suis has been associated with virulence.
De, A, Lupidi, Giulio, Petrelli, Dezemona, Vitali, Luca Agostino   +3 more
core   +1 more source

A detailed view of the intracellular transcriptome of Listeria monocytogenes in murine macrophages using RNA-seq [PDF]

, 2015
Listeria monocytogenes is a bacterial pathogen and causative agent for the foodborne infection listeriosis, which is mainly a threat for pregnant, elderly or immunocompromised individuals. Due to its ability to invade and colonize diverse eukaryotic cell
Alexander eGoesmann, Anita C. Windhorst, Gopala Krishna Mannala, Katrin eGentil, Markus eWeigel, Neda eFarmani, Rolf eHilker, Rolf eHilker, Tilman Gunter Schultze, Torsten eHain, Trinad eChakraborty   +10 more
core   +3 more sources

Caracterización parcial de una proteinasa coagulante de la leche aislada del alcaucil (Cynara scolymus L., Asteraceae) [PDF]

, 1997
The presence of proteinases in Cynara scolyrnus L. ( artichoke ) has been investigated by determining the proteolytic and milk clotting activities of crude extracts of different parts of the inflorescence in various stages of development, as well as of ...
Brutti, Cristina B., Caffini, Néstor Oscar, Llorente, Berta Elizabet, Natalucci, Claudia Luisa   +3 more
core  

Plant proteases and programmed cell death [PDF]

, 2019
Proteolysis affects many processes in plant development and during stress responses, as well as being crucial in cellular protein homeostasis and recycling of resources.
Gevaert, Kris, Nowack, Moritz, Stael, Simon, Van Breusegem, Frank   +3 more
core   +2 more sources

Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa

Journal of Psychiatric Research
Caseinolytic protease B (ClpB) produced by the gut enterobacteria displays anorexigenic effects possibly due to its molecular mimicry with α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide. ClpB is known to induce α-MSH cross-reactive antibodies previously associated with eating disorders.
Benjamin Thomas, Nadia Andrea Andreani, Emilie Lahaye, John F. Baines, Beate Herpertz-Dahlmann, Jochen Seitz, Sergueï O. Fetissov   +6 more
openaire   +2 more sources

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution

BMC Biotechnology, 2018
Background Mesophilic alkaline serine proteases from various bacteria have been commercially applied in a range of industries owing to their high catalytic efficiency and wide substrate specificity.
Hong-Yan Zhao, Hong Feng
doaj   +1 more source

The plasmid complement of the cheese isolate Lactococcus garvieae IPLA 31405 revealed adaptation to the dairy environment [PDF]

, 2017
Lactococcus garvieae is a lactic acid bacterium found in raw-milk dairy products as well as a range of aquatic and terrestrial environments. The plasmids in L.
Flórez García, Ana Belén, Mayo Pérez, Baltasar   +1 more
core   +1 more source

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding [PDF]

, 2010
ClpP is a self-compartmentalized protease, which has very limited degradation activity unless it associates with ClpX to form ClpXP or with ClpA to form ClpAP.
Barkow, Bewley, Bewley, Bogyo, Breusing, Brotz-Oesterhelt, Burton, Burton, Farrell, Flynn, Goldberg, Gottesman, Gottesman, Gottesman, Gribun, Grimaud, Groll, Hersch, Ingvarsson, Jenal, Jennings, Joshi, Kang, Kenniston, Kessel, Kim, Kim, Kim, Kirstein, Kwon, Levchenko, Liu, Martin, Martin, Martin, Mary E. Lee, Maurizi, Maurizi, Ortega, Powers, Rabl, Reinstein, Robert T. Sauer, Sauer, Siddiqui, Singh, Singh, Smith, Smith, Song, Sousa, Sousa, Striebel, Szyk, Tania A. Baker, Thompson, Thompson, Wang, Whitby, Yoo, Yu   +60 more
core   +1 more source