Results 201 to 210 of about 341,145 (337)

Lipopolysaccharide Inhibits Long Term Potentiation in the Rat Dentate Gyrus by Activating Caspase-1 [PDF]

, 2000
Emily Vereker, Veronica A. Campbell, Elizabeth Roche, Edel McEntee, Marina A. Lynch   +4 more
openalex   +1 more source

Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion

, 2009
PUBLISHED PMID: 19833722 IL-1? is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
O'NEILL, LUKE ANTHONY JOHN, CREAGH, EMMA
openaire   +2 more sources

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. [PDF]

Mol Med Rep
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S, Fei B.   +7 more
europepmc   +1 more source

Chlamydia trachomatis Infection of Epithelial Cells Induces the Activation of Caspase-1 and Release of Mature IL-18 [PDF]

, 2000
Hang Lu, Caixia Shen, Robert C. Brunham
openalex   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Novel strategies for PEDV to interfere with host antiviral immunity through Caspase-1. [PDF]

Virulence
Shi W, Xu W, Lv Q, Zhang Z, Fu X, Li D, He S, Wang Y, Xu J, Liu S, Ge Y, Li P, Ou C, Li X, Shi F.   +14 more
europepmc   +1 more source

Apoptosis induced by 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation [PDF]

, 2000
J. Moffatt
openalex   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Zerumbone Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the NLRP3/Caspase-1/GSDMD Signalling Pathway. [PDF]

J Cell Mol Med
Xu YJ, Fang FF, Zhao GQ, Yu WY, Han HY, Teng H, Lyu JN, Wang JF.   +7 more
europepmc   +1 more source