Results 221 to 230 of about 329,630 (269)

CD73 overexpression in ADSCs accelerates bladder repair by regulating the NFκB/NLRP3/caspase-1 signaling axis in neurogenic bladder rats. [PDF]

NPJ Regen Med
Zhu G, Zhang R, Huang J, Zhang Z, Zhao K, Yin X, Yang X, Jiang Z, Yang H, Bae WJ, Wang K.   +10 more
europepmc   +1 more source

Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway. [PDF]

Front Genet
Bian Z, Hao L, Yang R, Sun J.
europepmc   +1 more source

Involvement of LncRNA FAF in chemotherapy-induced cardiotoxicity by mediating pyroptosis through modulation of the NLRP3-Caspase-1 signaling pathway. [PDF]

Sci Rep
Feng Z, Sun J, Geng Q, He B, Zhang J, Ainiwaer Y, Zhang B, Zhang Y.   +7 more
europepmc   +1 more source

Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis. [PDF]

J Pain Res
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J.   +5 more
europepmc   +1 more source

Caspase-1/11 deficiency and cold exposure enhance the anti-tumor activity of brown adipose tissue secretome against breast cancer cells. [PDF]

Cancer Metab
Corrêa LH, Braz-de-Melo HA, Santos IO, Bezerra SP, Manchine JP, Lago NCS, Portacio-Santos CMA, Almeida RDN, Ribeiro DJS, Medeiros-Furquim T, Sant'ana LP, de Fragas MG, Lopes FT, Guerra RO, Câmara NOS, Castro MS, Fontes W, Zamboni DS, Magalhães KG.   +18 more
europepmc   +1 more source

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Caspase-1 activation by Salmonella

Trends in Cell Biology, 2003
Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Järveläinen, H., Galmiche, A., Zychlinsky, A.   +2 more
openaire   +3 more sources

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

Bioorganic & Medicinal Chemistry, 1999
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
K D, Brady, D A, Giegel, C, Grinnell, E, Lunney, R V, Talanian, W, Wong, N, Walker   +6 more
openaire   +2 more sources

Immunoblotting for Active Caspase-1

2013
Immunoblotting for caspase-1 is the gold-standard method of detecting inflammasome activation. In contrast to IL-1β-based readouts, it can be used in an experimental setup independent of de novo gene expression. Here, we present protocols for the preparation and precipitation of supernatant samples containing activated caspase-1 as well as protocols ...
Christopher, Jakobs, Eva, Bartok, Andrej, Kubarenko, Franz, Bauernfeind, Veit, Hornung   +4 more
openaire   +2 more sources

Assessing Caspase-1 Activation

2016
The caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1β) and IL-18. In this chapter, we describe the technique of Western blot to assess caspase-1 activation. This method provides multiple information within one experiment.
Guey, B., Petrilli, V.
openaire   +2 more sources

The design and synthesis of sulfonamides as caspase-1 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
William G, Harter, Hans, Albrect, Kenneth, Brady, Bradley, Caprathe, James, Dunbar, John, Gilmore, Sheryl, Hays, Catherine R, Kostlan, Beth, Lunney, Nigel, Walker   +9 more
openaire   +2 more sources