Results 1 to 10 of about 504,320 (308)

Caspase-1 inflammasomes in infection and inflammation [PDF]

Journal of Leukocyte Biology, 2007
AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed, Kanneganti, Thirumala‐devi, Franchi, Luigi, Núñez, Gabriel   +3 more
openaire   +4 more sources

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ahn, Avila-Flores, Brown, Cazzolli, Chen, Cross, Degterev, Du, Earnshaw, Farquhar, Fisher, Graham Ladds, Guimaraes, Hodgkin, Hui, Iwasaki-Bessho, Kasai, Kusner, Lim, Matthew N. Hodgkin, McDermott, Michelle H. Wright, Michelle J. Farquhar, Mina-olga Aletrari, Nakashima, Nozawa, Oh, O’Luanaigh, Palicz, Park, Ponting, Powner, Powner, Rozengurt, Samejima, Shi, Timmer, Wissing, Xie, Yamada, Zeniou-Meyer, Zhao, Zheng, Zhong   +43 more
core   +1 more source

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions [PDF]

The Journal of Cell Biology, 2000
Caspase-11, a member of the murine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine maturation. We demonstrate here that in addition to its defect in cytokine maturation, caspase-11–deficient mice have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery ...
S J, Kang, S, Wang, H, Hara, E P, Peterson, S, Namura, S, Amin-Hanjani, Z, Huang, A, Srinivasan, K J, Tomaselli, N A, Thornberry, M A, Moskowitz, J, Yuan   +11 more
openaire   +2 more sources

Caspase-1ζ, a new splice variant of the caspase-1 gene

Genomics, 2004
Five alternatively spliced mRNA isoforms of human caspase-1 have been identified previously and we report here the cloning of a new isoform, named CASP1 zeta (zeta), from human ovarian surface epithelial cell cDNA. The new isoform zeta is identical to the alpha isoform but missing 79 nucleotides in the coding region of the prodomain of procaspase-1 ...
Qiang, Feng, Peixiang, Li, Peter C K, Leung, Nelly, Auersperg   +3 more
openaire   +2 more sources

Caspase-1 Modulates Incisional Sensitization and Inflammation [PDF]

Anesthesiology, 2010
Background Surgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process.
De-Yong, Liang, XiangQi, Li, Wen-Wu, Li, Dennis, Fiorino, Yanli, Qiao, Peyman, Sahbaie, David C, Yeomans, J David, Clark   +7 more
openaire   +2 more sources

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +1 more source

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]

, 2020
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L.   +11 more
core   +1 more source

Apaf-1- and Caspase-8-independent apoptosis [PDF]

Cell Death & Differentiation, 2012
Two major apoptosis pathways, the mitochondrial and death receptor pathways, are well recognized. Here we established cell lines from the fetal thymus of Apaf-1-, Caspase-9-, or Bax/Bak-deficient mice. These cell lines were resistant to apoptosis induced by DNA-damaging agents, RNA or protein synthesis inhibitors, or stress in the endoplasmic reticulum.
Imao, T, Nagata, S
openaire   +2 more sources

Molecular mechanism of adipose tissue inflammation induced by acute exposure to cooking oil fumes

环境与职业医学
BackgroundCooking oil fumes are closely related to immune response, and adipose tissue also plays an important role in immune regulation. At present, the biological effect and mechanism of inflammation of adipose tissue induced by oil fume exposure are ...
Ge WANG, Biao WU, Jianshu GUO, Dongxia FAN, Lu YU, Chihang ZHANG, Lan MI, Lina WANG, Jinzhuo ZHAO   +8 more
doaj   +1 more source

NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease

Frontiers in Immunology
The NLRP3 inflammasome is a key cytosolic sensor in the innate immune system, activated by diverse danger signals such as metabolic stress, infections, and structural cellular disruptions.
María Virginia Pinzón-Fernández, Jhan S. Saavedra-Torres, Jhan S. Saavedra-Torres, Nelson Adolfo López Garzón, Jessica S. Pachon-Bueno, Francisco Javier Tamayo-Giraldo, María Camila Rojas Gomez, Marlon Arias-Intriago, Alice Gaibor-Pazmiño, Andrés López-Cortés, Juan S. Izquierdo-Condoy   +10 more
doaj   +1 more source