Results 1 to 10 of about 366,416 (307)

Assessing Caspase-1 Activation

, 2016
International audienceThe caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1beta) and IL-18.
Virginie Petrilli, Guey, B., Baptiste Guey, Petrilli, V.   +3 more
core   +3 more sources

Caspase-1 and caspase-8 cleave and inactivate cellular parkin [PDF]

Journal of Biological Chemistry, 2003
Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons.
CLARK, BFC, Clark, Brian F. C., Kahns, Søren, KAHNS, S, Jensen, Poul Henning, Vandenabeele, Peter, Jakobsen, Lene Diness, Kalai, Michaël, JENSEN, PH, JAKOBSEN, LD   +9 more
core   +6 more sources

Caspase-1 is an apical caspase leading to caspase-3 cleavage in the AIM2 inflammasome response, independent of caspase-8 [PDF]

Journal of Molecular Biology, 2017
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of IL-1β and IL-18.
James E. Vince, Vince, James E, Stacey, Katryn J, Vitaliya Sagulenko, Katryn J. Stacey, Parimala R. Vajjhala, Vitak, Nazarii, Nazarii Vitak, Vajjhala, Parimala, Sagulenko, Vitaliya   +9 more
core   +6 more sources

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +3 more sources

Pyroptosis- What We Know and the Road Ahead! [PDF]

Journal of Clinical and Diagnostic Research, 2022
Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil, Srinivas Prasad Vijayan, Roopa S Rao, Anil Sukumaran   +3 more
doaj   +1 more source

Isoflavone Attenuates the Caspase-1 and Caspase-3 Level in Cell Model of Parkinsonism [PDF]

Behavioural Neurology, 2015
The study has investigated the effect of isoflavone attenuates the caspase-1 and caspase-3 level in cell model of Parkinsonism. The subjects were PC12 cells.
Jian-xin Xu, Hai-ping Song, Qing-Xia Bu, De-Peng Feng, Xiao-Fan Xu, Qian-Ru Sun, Xue-Li Li   +6 more
doaj   +3 more sources

Quantifying caspase-1 activity in murine macrophages

, 2018
The caspase-1 protease is a core component of multiprotein inflammasome complexes, which play a critical role in regulating the secretion of mature, bioactive pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18.
Ross, Connie, Kate Schroder, Schroder, Kate, Amy Chan, Boucher, Dave, Chan, Amy, Connie Ross, Dave Boucher   +7 more
core   +5 more sources

Comparison of Transcriptome Responses between Sogatella furcifera Females That Acquired Southern Rice Black-Streaked Dwarf Virus and Not

Insects, 2022
The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

Cells, 2023
Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster, Abigail J. Dutton, Adina Yerzhan, Lindsay B. March, Katherine Barry, Corey R. Seehus, Xudong Huang, Sebastien Talbot, Clifford J. Woolf   +8 more
doaj   +1 more source

Vacuolar processing enzyme positively modulates plant resistance and cell death in response to Phytophthora parasitica infection

Journal of Integrative Agriculture, 2023
Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight, and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1 (RTP1) as
Xian-xian GAO, Ya-ling TANG, Qing-yao SHI, Yu-shu WEI, Xiao-xue WANG, Wei-xing SHAN, Xiao-yu QIANG   +6 more
doaj   +1 more source