Results 1 to 10 of about 329,482 (120)

Pyroptosis- What We Know and the Road Ahead! [PDF]

Journal of Clinical and Diagnostic Research, 2022
Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil, Srinivas Prasad Vijayan, Roopa S Rao, Anil Sukumaran   +3 more
doaj   +1 more source

A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

Cells, 2023
Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster, Abigail J. Dutton, Adina Yerzhan, Lindsay B. March, Katherine Barry, Corey R. Seehus, Xudong Huang, Sebastien Talbot, Clifford J. Woolf   +8 more
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Vacuolar processing enzyme positively modulates plant resistance and cell death in response to Phytophthora parasitica infection

Journal of Integrative Agriculture, 2023
Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight, and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1 (RTP1) as
Xian-xian GAO, Ya-ling TANG, Qing-yao SHI, Yu-shu WEI, Xiao-xue WANG, Wei-xing SHAN, Xiao-yu QIANG   +6 more
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Comparison of Transcriptome Responses between Sogatella furcifera Females That Acquired Southern Rice Black-Streaked Dwarf Virus and Not

Insects, 2022
The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj   +1 more source

Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus

Cells, 2023
In mammals, the circadian system controls various physiological processes to maintain metabolism, behavior, and immune function during a daily 24 h cycle.
Pikria Ketelauri, Katerina Scharov, Charlotte von Gall, Sonja Johann   +3 more
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Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Pathogens, 2020
Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson, Keman Xu, Fatma Saaoud, Gayani Nanayakkara, Nirag C. Jhala, Lu Liu, Charles Drummer, Yu Sun, Kwan N. Lau, Antonio Di Carlo, Xiaohua Jiang, Hong Wang, Sunil S. Karhadkar, Xiaofeng Yang   +13 more
doaj   +1 more source

Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus

Viruses, 2021
The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh, Michael T. McIntosh   +1 more
doaj   +1 more source

Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

eLife, 2023
Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang, Mohammad Anas, Jingsong Xu, Bisheng Zhou, Peter T Toth, Yamuna Krishnan, Anke Di, Asrar B Malik   +7 more
doaj   +1 more source

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Open Life Sciences, 2020
This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury.
Mai Zhen-Hao, Huang Yu, Huang Di, Huang Zi-Sheng, He Zhi-Xiang, Li Pei-Lin, Zhang Shuai, Weng Jie-Feng, Gu Wei-Li   +8 more
doaj   +1 more source