Results 21 to 30 of about 504,320 (308)

Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]

Journal of Biological Chemistry, 2003
Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren, Kalai, Michaël, Jakobsen, Lene Diness, Clark, Brian F. C., Vandenabeele, Peter, Jensen, Poul Henning   +5 more
openaire   +4 more sources

Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus

Viruses, 2021
The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh, Michael T. McIntosh   +1 more
doaj   +1 more source

Caspase‐1‐induced pyroptotic cell death [PDF]

Immunological Reviews, 2011
Summary:  Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised in this way, they can be lysed by pyroptosis,
Edward A, Miao, Jayant V, Rajan, Alan, Aderem   +2 more
openaire   +2 more sources

Caspase-1 activation of caspase-6 in human apoptotic neurons [PDF]

Cell Death & Differentiation, 2005
Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Here, we show that the Csp-1 inhibitor, Z-YVAD-fmk specifically prevents activation of Csp-6 and cell death in human neurons.
H, Guo, D, Pétrin, Y, Zhang, C, Bergeron, C G, Goodyer, A C, LeBlanc   +5 more
openaire   +2 more sources

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Open Life Sciences, 2020
This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury.
Mai Zhen-Hao, Huang Yu, Huang Di, Huang Zi-Sheng, He Zhi-Xiang, Li Pei-Lin, Zhang Shuai, Weng Jie-Feng, Gu Wei-Li   +8 more
doaj   +1 more source

Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

eLife, 2023
Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang, Mohammad Anas, Jingsong Xu, Bisheng Zhou, Peter T Toth, Yamuna Krishnan, Anke Di, Asrar B Malik   +7 more
doaj   +1 more source

Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]

Circulation Research, 2006
Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Blankenberg, S., Godefroy, T., Poirier, O., Rupprecht, H.J., Barbaux, S., Bickel, C., Nicaud, V., Schnabel, R., Kee, Frank, Morrison, C., Evans, Alun, Lackner, K.J., Cambien, F., Munzel, T., Tiret, L., Investigators, AtheroGene   +15 more
openaire   +3 more sources

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]

Journal of Biological Chemistry, 2009
Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Becker, Christine E., Creagh, Emma M., O'Neill, Luke A. J.   +2 more
openaire   +4 more sources