Results 41 to 50 of about 504,320 (308)

YopM Puts Caspase-1 on Ice [PDF]

Cell Host & Microbe, 2012
Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Jørgensen, Ine, Miao, Edward A.
openaire   +2 more sources

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Caspase-1: The inflammasome and beyond [PDF]

Innate Immunity, 2013
Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel, Strittmatter, Gerhard E, Garstkiewicz, Martha, Sand, Jennifer, Beer, Hans-Dietmar   +4 more
openaire   +3 more sources

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer [PDF]

, 2018
Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have ...
Aboagye, Eric O., Cleator, S., Coombes, R. C., Dubash, S. R., Heinzmann, K., Inglese, M., Kenny, Laura, Kozlowski, K., Lavdas, I., Lewanski, C., Lim, A. K., Masrour, N., Mauri, F., Merchant, S., Rama, N., Steel, J. F., Thornton, A.   +16 more
core   +1 more source

Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients

Toxins, 2021
NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schäfer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt   +10 more
doaj   +1 more source

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
doaj   +1 more source

IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]

, 2016
Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias, Baldi, Pablo Cesar, Campos, Priscila C., Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Muñoz González, Florencia, Oliveira, Sergio Costa, Vieira, Angelica T.   +9 more
core   +1 more source

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]

Journal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E, Stacey, Katryn J   +4 more
openaire   +3 more sources

Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis [PDF]

, 2018
Ultra-small gold nanoparticles, surface functionalised with a 50:50 ratio of a thiolated α-Galactose derivative and a thiolated hexaethylene glycol amine, are toxic to HSC-3 oral squamous carcinoma cells.
Espinosa Garcia, Cristina, Golding, Jon, Tzelepi, Konstantina, Williams, Phil   +3 more
core   +1 more source

Differential roles of caspase-1 and caspase-11 in infection and inflammation [PDF]

Scientific Reports, 2017
AbstractCaspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active forms. “ICE−/−” or “Casp1−/
Man, Si Ming, Karki, Rajendra, Briard, Benoit, Burton, Amanda R., Gingras, Sebastien, Pelletier, Stephane, Kanneganti, Thirumala-Devi   +6 more
openaire   +3 more sources