Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism [PDF]
, 2015 Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs)
A Dorfleutner +65 more
core +2 more sources
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Reports, 2020 Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos +6 more
doaj +1 more source
Genome-wide transcription analysis of interaction between the human macrophage and Mycobacterium tuberculosis during concurrent drug administration by conventional and novel methods [PDF]
, 2008 Targeted drug delivery to alveolar macrophages harboring Mycobacterium tuberculosis (Mtb) holds promise of high efficacy against pulmonary tuberculosis (TB).
Amit K. Singh +2 more
core +2 more sources
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]
, 2019 Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin +10 more
core +2 more sources
Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
doaj +1 more source
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. [PDF]
, 2017 Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with ...
Eder, C, Scholz, H
core +1 more source
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
Cell Reports, 2020 Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs +6 more
doaj +1 more source
Cells, 2022 The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget +3 more
doaj +1 more source
Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis [PDF]
, 2013 Programmed cell death (PCD) can play a crucial role in tuning the immune response to microbial infection. Although PCD can occur in different forms, all are mediated by a family of proteases called caspases.
Denise N. Bronner +2 more
core +1 more source
Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease [PDF]
Gut Microbes, 2016 A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2cmo).
Farrah C, Phillips +2 more
openaire +2 more sources