Results 11 to 20 of about 504,320 (308)

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +3 more sources

Pyroptosis- What We Know and the Road Ahead! [PDF]

Journal of Clinical and Diagnostic Research, 2022
Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil, Srinivas Prasad Vijayan, Roopa S Rao, Anil Sukumaran   +3 more
doaj   +1 more source

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent [PDF]

, 2014
Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were ...
A Ito, B Brand, C Coeshott, C Kebaier, C Riollet, D Demon, D Demon, Dario S. Zamboni, DD Bannerman, Dieter Demon, DJ Hazuda, E Brouillette, E Gonen, EM Ibeagha-Awemu, Evelyne Meyer, F Li, H Carlsen, Harald Carlsen, HW Barkema, J Gunther, J Mehrzad, J Monks, K Demeyere, K Farhat, K Jensen, K Persson-Waller, Koen Breyne, Kristel Demeyere, KW Kim, L Connelly, L Lara-Zárate, M Lamkanfi, M Rinaldi, M Wittmann, MG Stevens, Niek N. Sanders, OC Kousidou, Peter Vandenabeele, RA Black, S Balasubramanian, S Bougarn, S Elazar, S Elazar, S Liu, S Mandard, S Notebaert, S Notebaert, S Notebaert, SK Cool, Steven K. Cool, TC Lin, Tom Vandenberghe, U Meyer-Hoffert, U Schonbeck, W Yang, Wim Van Den Broeck, X Li, YH Schukken   +57 more
core   +16 more sources

Comparison of Transcriptome Responses between Sogatella furcifera Females That Acquired Southern Rice Black-Streaked Dwarf Virus and Not

Insects, 2022
The southern rice black-streaked dwarf virus (SRBSDV) is transmitted horizontally by Sogatella furcifera in a persistent, propagative manner. Exposure of S.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

Cells, 2023
Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster, Abigail J. Dutton, Adina Yerzhan, Lindsay B. March, Katherine Barry, Corey R. Seehus, Xudong Huang, Sebastien Talbot, Clifford J. Woolf   +8 more
doaj   +1 more source

Vacuolar processing enzyme positively modulates plant resistance and cell death in response to Phytophthora parasitica infection

Journal of Integrative Agriculture, 2023
Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight, and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1 (RTP1) as
Xian-xian GAO, Ya-ling TANG, Qing-yao SHI, Yu-shu WEI, Xiao-xue WANG, Wei-xing SHAN, Xiao-yu QIANG   +6 more
doaj   +1 more source

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj   +1 more source

Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus

Cells, 2023
In mammals, the circadian system controls various physiological processes to maintain metabolism, behavior, and immune function during a daily 24 h cycle.
Pikria Ketelauri, Katerina Scharov, Charlotte von Gall, Sonja Johann   +3 more
doaj   +1 more source

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice

Pathogens, 2020
Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson, Keman Xu, Fatma Saaoud, Gayani Nanayakkara, Nirag C. Jhala, Lu Liu, Charles Drummer, Yu Sun, Kwan N. Lau, Antonio Di Carlo, Xiaohua Jiang, Hong Wang, Sunil S. Karhadkar, Xiaofeng Yang   +13 more
doaj   +1 more source

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy [PDF]

Journal of the American Society of Nephrology, 2016
Glomerular apoptosis may contribute to diabetic nephropathy (dNP), but the pathophysiologic relevance of this process remains obscure. Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10 ...
Khurrum, Shahzad, Fabian, Bock, Moh'd Mohanad, Al-Dabet, Ihsan, Gadi, Shrey, Kohli, Sumra, Nazir, Sanchita, Ghosh, Satish, Ranjan, Hongjie, Wang, Thati, Madhusudhan, Peter P, Nawroth, Berend, Isermann   +11 more
openaire   +2 more sources