Results 201 to 210 of about 360,151 (357)

Protective mechanism of Korean Red Ginseng in cisplatin-induced ototoxicity through attenuation of nuclear factor-κB and caspase-1 activation

, 2012
Su‐Jin Kim, Hyun Jeong Kwak, DAE-SEUNG KIM, HYUN-MYUNG CHOI, Jung‐Eun Sim, Sung‐Hoon Kim, JAE-YOUNG UM, SEUNG-HEON HONG   +7 more
openalex   +2 more sources

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

F1Aα, a Death Receptor-binding Protein Homologous to theCaenorhabditis elegans Sex-determining Protein, FEM-1, Is a Caspase Substrate That Mediates Apoptosis

, 1999
Shing Leng Chan, Kuan Onn Tan, Li Zhang, Karen S. Yee, Francesca Ronca, Man‐Yee Chan, Victor C. Yu   +6 more
openalex   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Caspase‐1‐Dependent Pyroptosis of Peripheral Blood Mononuclear Cells Is Associated with the Severity and Mortality of Septic Patients [PDF]

, 2020
Yu-Chang Wang, Yukun Liu, Qinxin Liu, Qiang Zheng, Xijie Dong, Xinghua Liu, Wei Gao, Xiangjun Bai, Zhanfei Li   +8 more
openalex   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Caspase 1 overexpression in chronic pancreatitis due to ductular proliferation

, 2000
Marco Ramadani, Yinmo Yang, Frank Gansauge, Hans G. Beger, Susanne Gansauge   +4 more
openalex   +1 more source

The in vitro Mycobacterium bovis BCG Moreau infection of human monocytes that induces Caspase-1 expression, release and dependent cell death is mostly reliant upon cell integrity [PDF]

, 2019
Paulo R. Z. Antas, Carlos Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Thaize Quiroga Chometon, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, L.R.R. Castello-Branco, Rosa T. Pinho   +10 more
openalex   +1 more source

Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection [PDF]

, 2023
Camila Marques-da-Silva, Clyde Schmidt-Silva, Rodrigo P. Baptista, Samarchith P. Kurup   +3 more
openalex   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source