Results 251 to 260 of about 24,095,126 (372)

Apoptosis induced by 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation [PDF]

, 2000
J. Moffatt
openalex   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

Advanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro, Marta Aranda Palomer, Margarida Esteves, Carolina Rodrigues, José Maria Fernandes, Francisca Oliveira, Alexandra Teixeira, Carlos Honrado, Lorena Dieguez, Sara Abalde‐Cela, Miguel Xavier   +10 more
wiley   +1 more source

Paris saponin VII attenuates psoriasiform inflammation by regulating STAT3/NFκB signaling pathway and Caspase-1-induced pyroptosis. [PDF]

Mol Med
Zhou X, Ning J, Wu D, Liu Q, Jiang W, Liu J, Cai R, Liu D, Bai Y.   +8 more
europepmc   +1 more source

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8 [PDF]

, 2000
Henning R. Stennicke, Martin Renatus, Morten Meldal, Guy S. Salvesen   +3 more
openalex   +1 more source

Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening

Advanced Science, EarlyView.
Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin, Joungpyo Lim, Seewoo Kim, Sangeun Lee, Wei Wen Su, Jinho Yoon, Jeong‐Woo Choi   +6 more
wiley   +1 more source

The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse. [PDF]

PLoS One
Rabhi BV, Thomasseau S, Decrouy X, Cohen-Solal M, Deckert M, Coudert AE, Brial F.   +6 more
europepmc   +1 more source

Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells [PDF]

, 2000
Verónica Galván, Renato Brandimarti, Joshua Munger, Bernard Roizman   +3 more
openalex   +1 more source

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source

Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis. [PDF]

Front Pharmacol
Liu Z, Lv L, Wei J, Xie Y, Jili M, Huang Y, Yang R, Luo Y.   +7 more
europepmc   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source