Results 271 to 280 of about 21,606,107 (313)

Involvement of LncRNA FAF in chemotherapy-induced cardiotoxicity by mediating pyroptosis through modulation of the NLRP3-Caspase-1 signaling pathway. [PDF]

Sci Rep
Feng Z, Sun J, Geng Q, He B, Zhang J, Ainiwaer Y, Zhang B, Zhang Y.   +7 more
europepmc   +1 more source

Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis. [PDF]

J Pain Res
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J.   +5 more
europepmc   +1 more source

Differential Expression of Galectin-3, Caspase-1, and Phosphorylated P53: Diagnostic Biomarkers for Basal Cell Carcinoma: A Case-Control Study. [PDF]

Health Sci Rep
Niamoradi M, Babajani F, Roghani SA, Goodarzi MT, Asadi S.   +4 more
europepmc   +1 more source

Taurine attenuates <i>Listeria monocytogenes</i>-induced inflammation and pyroptosis in mouse model by regulating MAPK and NLRP3/caspase-1/GSDMD pathways. [PDF]

mSystems
Liu T, Zhang X, Qi Z, Zheng X, Weng Y, Han X.   +5 more
europepmc   +1 more source

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Caspase-1 activation by Salmonella

Trends in Cell Biology, 2003
Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Järveläinen, H., Galmiche, A., Zychlinsky, A.   +2 more
openaire   +3 more sources

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

Bioorganic & Medicinal Chemistry, 1999
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
K D, Brady, D A, Giegel, C, Grinnell, E, Lunney, R V, Talanian, W, Wong, N, Walker   +6 more
openaire   +2 more sources

Immunoblotting for Active Caspase-1

2013
Immunoblotting for caspase-1 is the gold-standard method of detecting inflammasome activation. In contrast to IL-1β-based readouts, it can be used in an experimental setup independent of de novo gene expression. Here, we present protocols for the preparation and precipitation of supernatant samples containing activated caspase-1 as well as protocols ...
Christopher, Jakobs, Eva, Bartok, Andrej, Kubarenko, Franz, Bauernfeind, Veit, Hornung   +4 more
openaire   +2 more sources

Sennoside A is a novel inhibitor targeting caspase-1

Food & Function, 2022
Sen A decreases caspase-1 activity and P2X7 function, which further leads to NLRP3 and AIM2 inflammasome disassembly and the reduced secretion of IL-1β and IL-18viapyroptosis restraining and NF-κB-involved NLRP3 priming.
Jiasi Wu, Yuejia Lan, Xiaoke Shi, Wenge Huang, Sheng Li, Jizhou Zhang, Huan Wang, Fei Wang, Xianli Meng   +8 more
openaire   +2 more sources

The intricate biophysical puzzle of caspase-1 activation

Archives of Biochemistry and Biophysics, 2021
This review takes a closer look at the structural components of the molecules involved in the processes leading to caspase-1 activation. Interleukins 1β and 18 (IL-1β, IL-18) are well-known proinflammatory cytokines that are produced following cleavage of their respective precursor proteins by the cysteine protease caspase-1.
Nyasha J. Makoni, Michael R. Nichols
openaire   +2 more sources

The design and synthesis of sulfonamides as caspase-1 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
William G, Harter, Hans, Albrect, Kenneth, Brady, Bradley, Caprathe, James, Dunbar, John, Gilmore, Sheryl, Hays, Catherine R, Kostlan, Beth, Lunney, Nigel, Walker   +9 more
openaire   +2 more sources