Results 281 to 290 of about 21,606,107 (313)

Caspase-1: an integral regulator of innate immunity

Seminars in Immunopathology, 2015
Caspase-1 is a unique cysteine protease playing central roles in innate immunity. Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated by proximity-induced autoproteolysis in multimeric protein complexes called the inflammasome. Active caspase-1 induces secretion of pro-inflammatory cytokines and mediates pyroptosis,
Stefan, Winkler, Angela, Rösen-Wolff
openaire   +2 more sources

Obesity development in caspase-1-deficient mice

International Journal of Obesity, 2013
Caspase-1 is a member of the intracellular cysteine protease family that mediates inflammation through the activation of the cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). As mice lacking IL-18 become obese and insulin resistant, and both IL-18 and IL-1β have a role in overall energy balance, we sought to determine whether caspase-1 ...
H, Wang, W, Capell, J H, Yoon, S, Faubel, R H, Eckel   +4 more
openaire   +2 more sources

Nucleotide Sequence of Equine Caspase-1 cDNA

DNA Sequence, 1999
Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides.
S, Wardlow, M N, Penha-Goncalves, D J, Argyle, D E, Onions, L, Nicolson   +4 more
openaire   +2 more sources

Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages

Inflammation, 2012
Sevoflurane is one of the most commonly used volatile anesthetics. Recent studies have shown that sevoflurane plays an important role in modulation of inflammation and immunity. However, little is known about the related molecular mechanisms. This study was designed to investigate the effects and mechanisms of sevoflurane on inflammatory cell death ...
Yue, Jin, Hui, Li, Guohao, Xie, Shuzhen, Chen, Shuijin, Wu, Xiangming, Fang   +5 more
openaire   +2 more sources

Inhibitors of TACE and Caspase-1 As Anti-inflammatory Drugs

Current Medicinal Chemistry, 2005
TNF-α neutralising agents such as Infliximab (Remicade®), Etanercept (Enbrel®) and the IL-1 receptor antagonist Anakinra (Kineret®), are currently used clinically for the treatment of many inflammatory diseases such as Crohns disease, rheumatoid arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis, psoriatic arthritis and psoriasis ...
Le, Giang T, Abbenante, Giovanni
openaire   +6 more sources

The protease caspase-1: Activation pathways and functions

Biochemical and Biophysical Research Communications
Caspase-1 is one of the main mediators of inflammatory caspases and has become a correspondent with inflammation, cell death, and several inflammatory diseases. In this review, we systematically summarize both original and recent advances in caspase-1 to provide references for a better understanding of the molecular mechanisms in its activation and ...
Hongmin, Zhen, Yumeng, Hu, Xiaoyan, Liu, Guangsen, Fan, Shuna, Zhao   +4 more
openaire   +2 more sources

Plaguing Caspase-1 Through Rac

Science's STKE, 2004
The Yersinia bacteria, whose most notorious member ( Y. pestis ) is the organism that causes bubonic plague, inject Yop proteins into target cells. The individual Yop effectors, which cooperate to prevent phagocytosis and suppress the inflammatory response, have highly specific effects.
openaire   +1 more source

Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion

2009
PUBLISHED
O'NEILL, LUKE ANTHONY JOHN, CREAGH, EMMA
openaire   +2 more sources

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki
exaly  

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Immunity, 2020
Bart Tummers, Luigi Mari, Bradlee L Heckmann   +2 more
exaly