Results 311 to 320 of about 360,151 (357)

HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression. [PDF]

Cell Death Dis
Padia R, Sun L, Liao YF, Calbay O, Chi C, Akter M, Wu L, Fu Z, Zhang DD, Huang S.   +9 more
europepmc   +1 more source

Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway. [PDF]

J Mol Histol
Wu X, Hou YL, Wang TX, Chang LP, Zhou HR, Wang MY, Wu YL.   +6 more
europepmc   +1 more source

Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 Pathway. [PDF]

CNS Neurosci Ther
Zheng F, Yan L, Ren F, Cai W, Lan Y, Chen H, Chen Q, Weng G.   +7 more
europepmc   +1 more source

Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells. [PDF]

J Inflamm Res
Li J, Han L, Feng S, Lin G, Zou G, Huang T, Ran T, Zhao X.   +7 more
europepmc   +1 more source

Renoprotective impact of tiron against diclofenac-induced nephrotoxicity: targeting TLR4/NF-κB/NLRP3/Caspase-1/IL1-β pathway. [PDF]

BMC Pharmacol Toxicol
Ragab AS, El-Kelany AS, Sewilam HM, El-Kashef DH.   +3 more
europepmc   +1 more source

The FIIND Domain of Nlrp1b Promotes Oligomerization and Pro-caspase-1 Activation in Response to Lethal Toxin of Bacillus anthracis

, 2012
Vineet Joag
openalex   +1 more source

Corrigendum to "miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury". [PDF]

J Immunol Res
europepmc   +1 more source

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Caspase-1 activation by Salmonella

Trends in Cell Biology, 2003
Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Järveläinen, H., Galmiche, A., Zychlinsky, A.   +2 more
openaire   +3 more sources

Assessing Caspase-1 Activation

2016
The caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1β) and IL-18. In this chapter, we describe the technique of Western blot to assess caspase-1 activation. This method provides multiple information within one experiment.
Guey, B., Petrilli, V.
openaire   +2 more sources

Immunoblotting for Active Caspase-1

2013
Immunoblotting for caspase-1 is the gold-standard method of detecting inflammasome activation. In contrast to IL-1β-based readouts, it can be used in an experimental setup independent of de novo gene expression. Here, we present protocols for the preparation and precipitation of supernatant samples containing activated caspase-1 as well as protocols ...
Christopher, Jakobs, Eva, Bartok, Andrej, Kubarenko, Franz, Bauernfeind, Veit, Hornung   +4 more
openaire   +2 more sources