Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao +2 more
wiley +1 more source
Corrigendum to: RGS2 promotes brain metastasis of cisplatin-resistant non-small cell lung cancer through caspase-1/IL-1beta signaling pathway. [PDF]
europepmc +1 more source
NLRP3/Caspase-1 Regulate Macrophage Efferocytosis by Modulating ADAM17-Mediated MerTK Cleavage in Liver Ischemia-Reperfusion Injury. [PDF]
Guan G +10 more
europepmc +1 more source
Yipishen Xiezhuo Jiedu Decoction in Ameliorating Kidney Damage Through miR-223/NLRP3/ Caspase-1 Pathway [PDF]
Weng J +7 more
europepmc +1 more source
NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery. [PDF]
Palomäki VA +5 more
europepmc +1 more source
Dihydromyricetin exerts neuroprotective effects in acute spinal cord injury by inhibiting NLRP3/Caspase-1 inflammasome through gut microbiome modeling. [PDF]
Yang Y +8 more
europepmc +1 more source
Avian coronaviruses induce inflammatory responses by activating p38/MAPK signaling and NLRP3/caspase-1 inflammasomes through sphingosine-1-phosphate receptor 1. [PDF]
Xiao H +8 more
europepmc +1 more source
Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats. [PDF]
León Silva AH +13 more
europepmc +1 more source
Assessing Caspase-1 Activation
The caspase-1 enzymatic activity plays a major role in the innate immune response as it regulates the maturation of two major proinflammatory cytokines, the interleukin-1beta (IL-1β) and IL-18. In this chapter, we describe the technique of Western blot to assess caspase-1 activation. This method provides multiple information within one experiment.
Guey, B., Petrilli, V.
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