Results 311 to 320 of about 24,095,126 (372)

Caspase 1 overexpression in chronic pancreatitis due to ductular proliferation

, 2000
Marco Ramadani, Yinmo Yang, Frank Gansauge, Hans G. Beger, Susanne Gansauge   +4 more
openalex   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Caspase-1 Variants and Plasma IL-1β in Patients with Leishmania guyanensis Cutaneous Leishmaniasis in the Amazonas. [PDF]

Int J Mol Sci
de Souza JL, de Farias Guerra MV, de Mesquita TGR, Junior JDES, Sequera HDG, da Silva LS, da Silva LA, Moura FM, Menescal LSF, da Costa Torres J, Pinheiro SK, Kerr HKA, Ogusku MM, de Souza MLG, de Moura Neto JP, Sadahiro A, Ramasawmy R.   +16 more
europepmc   +1 more source

Role of CD95-activated caspase-1 processing of IL-1β in TCR-mediated proliferation of HIV-infected CD4+ T cells

, 2001
Frédéric Petit, Jacques Corbeil, Jean‐Daniel Lelièvre, Laure Moutouh–de Parseval, Grégory Pinon, Douglas R. Green, Jean Claude Ameisen, Jérôme Estaquier   +7 more
openalex   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

<i>Lycium barbarum</i> Polysaccharides Alleviate Ethanol-Induced Liver Injury by Activating PPAR-α and Inhibiting NLRP-3/Caspase-1-Mediated Pyroptosis. [PDF]

Food Sci Nutr
Cai LB, Zhou Q, Tao N, Chen WZ.
europepmc   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression. [PDF]

Nat Cardiovasc Res
Moreno-Loaiza O, Soares VC, de Assumpção Souza M, Vera-Nuñez N, Rodriguez de Yurre Guirao A, da Silva TP, Pozes AB, Perticarrari L, Monteiro E, Albino MC, Silva SB, Dias SSG, Maciel L, Muzi-Filho H, de Oliveira DF, Braga BC, Diniz LP, Cruz MC, Barbosa SR, Castro-Junior AB, Conde L, Cabral-Castro MJ, de Souza OF, Tavares Pinheiro MV, Araújo de Oliveira Junior N, Rezende de Siqueira L, Cosenza RP, Munhoz da Fontoura C, Secco JCP, da Rocha Ferreira J, Silvestre de Sousa A, Albuquerque D, Luiz RR, Nicolau-Neto P, Pretti MA, Boroni M, Bonamino MH, Kasai-Brunswick TH, Mello DB, Gonçalves-Silva T, Ramos IP, Bozza FA, Madeiro JPDV, Pedrosa RC, Carneiro-Ramos MS, da Silva Martinho H, Bozza PT, Mesquita de Souza F, Victor Lucena da Silva G, Cunha TM, Uzelac I, Fenton F, Moll-Bernardes R, Paiva CN, Escobar AL, Medei E.   +55 more
europepmc   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source