Results 311 to 320 of about 341,145 (337)

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Detection of NLRP3, ASC, and Caspase-1 in serum and cerebrospinal fluid of traumatic brain injury patients: implications for short-term prognosis. [PDF]

Acta Neurol Belg
Aihemaitiniyazi A, Ma K, Xu J, Chen H, Liu X, Li J.   +5 more
europepmc   +1 more source

Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata. [PDF]

Biomol Biomed
Zhang J, Li Z, Liu K, Du X, Yao T, Ye J.
europepmc   +1 more source

Caspase-1 Variants and Plasma IL-1β in Patients with Leishmania guyanensis Cutaneous Leishmaniasis in the Amazonas. [PDF]

Int J Mol Sci
de Souza JL, de Farias Guerra MV, de Mesquita TGR, Junior JDES, Sequera HDG, da Silva LS, da Silva LA, Moura FM, Menescal LSF, da Costa Torres J, Pinheiro SK, Kerr HKA, Ogusku MM, de Souza MLG, de Moura Neto JP, Sadahiro A, Ramasawmy R.   +16 more
europepmc   +1 more source

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway. [PDF]

Front Pharmacol
An N, Wang X, Qin J, Cheng M, Bai M, Cheng J, Xu Q, Wu X.   +7 more
europepmc   +1 more source

Caspase-1-dependent pyroptosis converts αSMA⁺ CAFs into collagen-III^high iCAFs to fuel chemoresistant cancer stem cells. [PDF]

Sci Adv
Gao H, Wong SQR, Subel E, Huang YH, Lee YC, Hayashi K, Alonzo ME, Karabicici M, Hoi XP, Kasabyan A, Mo Q, Melchiode Z, El-Zaatari Z, Shen S, Satkunasivam R, Nikolos F, Chan KS.   +16 more
europepmc   +1 more source

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Caspase-1 activation by Salmonella

Trends in Cell Biology, 2003
Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Harri A. Järveläinen, Antoine Galmiche, Arturo Zychlinsky   +2 more
openaire   +3 more sources

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

Bioorganic & Medicinal Chemistry, 1999
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
Christine Grinnell, Winnie W. Wong, Kenneth Dale Brady, Robert V. Talanian, Elizabeth A. Lunney, David A. Giegel, Nigel Walker   +6 more
openaire   +3 more sources