Results 261 to 270 of about 460,615 (302)

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Modulation of SIRT-1, NF-κB/TNF-α/IL-6, and ERK/Caspase-3 by Lutein Mitigates Methotrexate-Induced Hepatotoxicity. [PDF]

Pharmaceuticals (Basel)
Abdelwahab AM, Habib HA, Darwish MA, Bin Jardan YA, Heeba GH.   +4 more
europepmc   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase-3 and Aifm1 Splicing Pathways. [PDF]

Adv Sci (Weinh)
Chen L, Li Y, Yu Y, Cai M, Li H, Huang M, Yang G, Guo J, Wang H, Song Z, Shen W, Jiang H, Wu H.   +12 more
europepmc   +1 more source

A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer. [PDF]

J Nanobiotechnology
Zhang Y, Yang E, Zhang X, Shi Y, Fan G, Wang Y, Tian J, Wang H, Dong Z, Wang Y, Cheng L, Zhao Z, Zhang Y, Wang B, Wang Z.   +14 more
europepmc   +1 more source

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis. [PDF]

Invest Ophthalmol Vis Sci
Kan J, Song S, Liu M, Xu Q, Lee J, Sun J, Xue S, Sun X, Che C.   +8 more
europepmc   +1 more source

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Caspase-3 Activators as Anticancer Agents

Current Protein & Peptide Science, 2023
Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
openaire   +2 more sources

MK2 Phosphorylates Caspase‐3, Facilitates Nuclear Translocation of Caspase 3, and Regulates Apoptosis

The FASEB Journal, 2022
Background Apoptosis is a necessary and key pathologic feature in the development of acute lung injury (ALI). Previous research has identified MAPK Activated Protein Kinase 2 (MK2) as a potential regulator in the development of apoptosis, by facilitating the nuclear translocation of active caspase‐3, the ...
Othello Lance Del Rosario, Karthik Suresh, Larissa Shimoda, Madhavi Rane, Mahendra Damarla   +4 more
openaire   +1 more source