Results 241 to 250 of about 476,553 (353)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis. [PDF]

Commun Biol
Lu T, Song Y, Liang K, Zhang Z, Li Y, Tan X, Li X, Li F.   +7 more
europepmc   +1 more source

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

, 2011
Paulo M.C. Glória, Isabel Coutinho, Lídia Gonçalves, Cristina M. S. G. Baptista, Joana Soares, Ana S. Newton, Rui Moreira, Lucı́lia Saraiva, Maria M. M. Santos   +8 more
openalex   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Therapeutic Exosomes Carrying VEGFA siRNA Inhibit Pathological Corneal Angiogenesis via PI3K-Akt-Caspase-3 Signaling. [PDF]

Biomedicines
Hur W, Bhujel B, Lee S, Oh S, Chung HS, Lee H, Kim JY.   +6 more
europepmc   +1 more source

Activation of Caspases-3, -6, and -9 during Finasteride Treatment of Benign Prostatic Hyperplasia [PDF]

, 2005
Aline Bözec, A. Ruffion, Myriam Decaussin, Jean André, M. Devonec, Mohamed Benahmed, Claire Mauduit   +6 more
openalex   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Super-Sensitive Chemiluminescent Probe for the Detection of Caspase-3 Activity. [PDF]

Bioconjug Chem
Tannous R, Zhang C, Shabat D.
europepmc   +1 more source

Imuno-expressão de Cox-2, Caspase 3, Ki67 e Survivina em tumor venéreo transmissível canino.

, 2015
Sandra Bassani Silva, Haline Feo Ballesteros, Luis Maurício Montoya Flórez, Noeme Sousa Rocha   +3 more
openalex   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source