Results 231 to 240 of about 335,404 (264)

Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
openaire   +2 more sources

Prognostic Significance of the Immunohistochemical Staining of Cleaved Caspase-3, an Activated Form of Caspase-3, in Gliomas

Clinical Cancer Research, 2007
Abstract Purpose: Gliomas are common tumors of the central nervous system, and the majority of patients with gliomas have a poor prognosis. The prediction of prognosis is very important in selecting treatment. In the present study, we retrospectively examined the immunohistochemical staining of cleaved caspase-3 (CC3), an activated form ...
Tatsuya, Kobayashi, Junya, Masumoto, Tsuyoshi, Tada, Tetsuo, Nomiyama, Kazuhiro, Hongo, Jun, Nakayama   +5 more
openaire   +2 more sources

Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice

Apoptosis, 2004
Caspase-3 is a potential therapeutic target for a number of degenerative diseases. However the development of specific caspase-3 inhibitors has been hampered by inter-species differences and the high degree of homology shared by different caspases.
L E, Kerr, J-L A, Birse-Archbold, A, Simon, N, Logan, F, Scott, G, Carlson, D W, Nicholson, J S, Kelly, J, Sharkey   +8 more
openaire   +2 more sources

FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells

Nanoscale, 2013
By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC-quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.
Anming, Tang, Bin, Mei, Weijuan, Wang, Wanglai, Hu, Fang, Li, Jun, Zhou, Qing, Yang, Hua, Cui, Mian, Wu, Gaolin, Liang   +9 more
openaire   +2 more sources

Survivin does not inhibit caspase-3 activity

Blood, 2000
Conway et al recently reported that alternatively spliced forms of mouse survivin exhibit different antiapoptotic properties.[1][1] This was inferred from inhibition of recombinant caspase-3 catalytic activity using a standard chromogenic assay in the presence of increasing concentrations ...
D P, Banks, J, Plescia, D C, Altieri, J, Chen, S H, Rosenberg, H, Zhang, S C, Ng   +6 more
openaire   +2 more sources

Caspase 3 and 8 deficiency in human neuroblastoma

Cancer Genetics and Cytogenetics, 2003
An altered apoptotic response represents a pivotal feature of cancer and is involved in cancerogenesis and resistance to chemotherapy. So far, however, only a few studies have been devoted to survey caspase content in malignant cell lines and primary tumor specimens. In this report, we investigated the expression of two pivotal caspases, 3 and 8, in 63
IOLASCON A, BORRIELLO, Adriana, GIORDANI L, CUCCIOLLA V, MORETTI A, MONNO F, CRINITI V, MARZULLO A, CRISCUOLO M, DELLA RAGIONE, Fulvio   +9 more
openaire   +4 more sources

Blockade of processing/activation of caspase-3 by hypoxia

Biochemical and Biophysical Research Communications, 2008
Tumor hypoxia, which is caused by the rapid proliferation of tumor cells and aberrant vasculature in tumors, results in inadequate supplies of oxygen and nutrients to tumor cells. Paradoxically, these unfavorable growth conditions benefit tumor cell survival, although the mechanism is poorly understood.
Sang Hee, Han, Moonil, Kim, Kyoungsook, Park, Tae-Hyoung, Kim, Dai-Wu, Seol   +4 more
openaire   +2 more sources

Caspase 3 in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2003
An inability to undergo apoptosis is widely thought to contribute to both tumorigenesis and tumor progression. One of the key mediators of apoptosis is the thiol protease caspase 3. In this investigation, caspase 3 mRNA and protein expression in breast cancer was examined.Caspase 3 was measured at the mRNA level using reverse transcription-PCR and at ...
Norma, O'Donovan, John, Crown, Helen, Stunell, Arnold D K, Hill, Enda, McDermott, Niall, O'Higgins, Michael J, Duffy   +6 more
openaire   +1 more source

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Cell, 2020
Min Zheng, Rajendra Karki
exaly  

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Immunity, 2020
Bart Tummers, Luigi Mari, Bradlee L Heckmann   +2 more
exaly