Results 221 to 230 of about 335,404 (264)

Non-genetic inactivation of caspase-3 and P53 increases cancer cell fitness by PDIA4 redistribution. [PDF]

Oncogene
Twito G, Abu Abayed FA, Gilad A, Biadsy S, Gavriel N, Sheikh Suliman S, Mizrahi Y, Megged H, Tenenboim M, Abu-Freha N, Igbaria A.   +10 more
europepmc   +1 more source

Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway. [PDF]

CNS Neurosci Ther
Wu S, Zhou Y, Pei Z, Wang Y, Zhang Z.
europepmc   +1 more source

Activity-dependent synapse elimination requires caspase-3 activation. [PDF]

Elife
Yu Z, Gutu A, Kim N, O'Shea EK.
europepmc   +1 more source

Unlocking caspase-8 enables Pt(IV) to trigger robust caspase-3/GSDME-mediated pyroptosis via drug co-delivery in chemoresistant bladder cancer. [PDF]

J Nanobiotechnology
Wen J, Zhou B, Zhang H, Tang Y, Hu H, Xiao H, Ge B.   +6 more
europepmc   +1 more source

RETRACTION: Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins. [PDF]

Biomed Res Int
Research International B.
europepmc   +1 more source

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity. [PDF]

Cell Death Dis
Berthenet K, Diazzi S, Jamard C, Stopa KB, Gil C, Dragan S, Fanfone D, Nguyen TT, Al N, Virard F, Meurette O, Popgeorgiev N, Hernandez-Vargas H, Ablain J, Ichim G.   +14 more
europepmc   +1 more source

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Caspase-3 Activators as Anticancer Agents

Current Protein & Peptide Science, 2023
Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
openaire   +2 more sources

MK2 Phosphorylates Caspase‐3, Facilitates Nuclear Translocation of Caspase 3, and Regulates Apoptosis

The FASEB Journal, 2022
Background Apoptosis is a necessary and key pathologic feature in the development of acute lung injury (ALI). Previous research has identified MAPK Activated Protein Kinase 2 (MK2) as a potential regulator in the development of apoptosis, by facilitating the nuclear translocation of active caspase‐3, the ...
Othello Lance Del Rosario, Karthik Suresh, Larissa Shimoda, Madhavi Rane, Mahendra Damarla   +4 more
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Posttranslational Regulation of Bim by Caspase‐3

Annals of the New York Academy of Sciences, 2007
Abstract:  Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably ...
Hidetoshi, Wakeyama, Toru, Akiyama, Yuho, Kadono, Masaki, Nakamura, Yasushi, Oshima, Kozo, Nakamura, Sakae, Tanaka   +6 more
openaire   +2 more sources