Results 221 to 230 of about 336,159 (263)

A Caspase-3-Activatable Near-Infrared AIEgen for Tumor Apoptosis Imaging In Vivo. [PDF]

Chem Biomed Imaging
Xu L, Jin Y, Yang Z, Zhan W, Liang G, Shen S.   +5 more
europepmc   +1 more source

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity. [PDF]

Cell Death Dis
Berthenet K, Diazzi S, Jamard C, Stopa KB, Gil C, Dragan S, Fanfone D, Nguyen TT, Al N, Virard F, Meurette O, Popgeorgiev N, Hernandez-Vargas H, Ablain J, Ichim G.   +14 more
europepmc   +1 more source

RETRACTION: Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins. [PDF]

Biomed Res Int
Research International B.
europepmc   +1 more source

Unlocking caspase-8 enables Pt(IV) to trigger robust caspase-3/GSDME-mediated pyroptosis via drug co-delivery in chemoresistant bladder cancer. [PDF]

J Nanobiotechnology
Wen J, Zhou B, Zhang H, Tang Y, Hu H, Xiao H, Ge B.   +6 more
europepmc   +1 more source

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Caspase-3 Activators as Anticancer Agents

Current Protein & Peptide Science, 2023
Background: The cancer is still a major cause of death worldwide. Among different targets to design anticancer agents, caspase-3 is an important target as its cleavage and activation lead to apoptosis and finally, cancer cell death. Apart from some naturally occurring molecules, many small molecules have been reported as caspase-3 activators ...
Nitin Srivastava, Anil Kumar Saxena
openaire   +2 more sources

MK2 Phosphorylates Caspase‐3, Facilitates Nuclear Translocation of Caspase 3, and Regulates Apoptosis

The FASEB Journal, 2022
Background Apoptosis is a necessary and key pathologic feature in the development of acute lung injury (ALI). Previous research has identified MAPK Activated Protein Kinase 2 (MK2) as a potential regulator in the development of apoptosis, by facilitating the nuclear translocation of active caspase‐3, the ...
Othello Lance Del Rosario, Karthik Suresh, Larissa Shimoda, Madhavi Rane, Mahendra Damarla   +4 more
openaire   +1 more source

Posttranslational Regulation of Bim by Caspase‐3

Annals of the New York Academy of Sciences, 2007
Abstract:  Bim is a proapoptotic BH3‐domain‐only member of the Bcl‐2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably ...
Hidetoshi, Wakeyama, Toru, Akiyama, Yuho, Kadono, Masaki, Nakamura, Yasushi, Oshima, Kozo, Nakamura, Sakae, Tanaka   +6 more
openaire   +2 more sources

Novel zebrafish caspase-3 substrates

Biochemical and Biophysical Research Communications, 2007
The zebrafish model has been widely used to investigate numerous signaling pathways in vertebrates, including programmed cell death. Although several zebrafish proteins homologous to mammalian caspases have been identified, our understanding of these zebrafish caspases is still limited.
C Alexander, Valencia, Christian, Bailey, Rihe, Liu   +2 more
openaire   +2 more sources

Prognostic Significance of the Immunohistochemical Staining of Cleaved Caspase-3, an Activated Form of Caspase-3, in Gliomas

Clinical Cancer Research, 2007
Abstract Purpose: Gliomas are common tumors of the central nervous system, and the majority of patients with gliomas have a poor prognosis. The prediction of prognosis is very important in selecting treatment. In the present study, we retrospectively examined the immunohistochemical staining of cleaved caspase-3 (CC3), an activated form ...
Tatsuya, Kobayashi, Junya, Masumoto, Tsuyoshi, Tada, Tetsuo, Nomiyama, Kazuhiro, Hongo, Jun, Nakayama   +5 more
openaire   +2 more sources

Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice

Apoptosis, 2004
Caspase-3 is a potential therapeutic target for a number of degenerative diseases. However the development of specific caspase-3 inhibitors has been hampered by inter-species differences and the high degree of homology shared by different caspases.
L E, Kerr, J-L A, Birse-Archbold, A, Simon, N, Logan, F, Scott, G, Carlson, D W, Nicholson, J S, Kelly, J, Sharkey   +8 more
openaire   +2 more sources