Results 21 to 30 of about 16,739,924 (339)
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Cell Death Discovery, 2020 Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang +3 more
semanticscholar +1 more source
Caspase-3, Shears for Synapse Pruning [PDF]
Developmental Cell, 2014 Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced ...
Wen Cheng Xiong +5 more
openaire +3 more sources
Aquaculture and Fisheries, 2021 During low tide intertidal organisms face severe temperature fluctuations. This situation may be more pronounced in the context of climate change.
Fengshen Zhao, Heding Shen
doaj +1 more source
Huntingtin inhibits caspase-3 activation [PDF]
The EMBO Journal, 2006 Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Ioannis Dragatsis +7 more
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Overexpression of caspase-3 in hepatocellular carcinomas [PDF]
Modern Pathology, 2004 Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra Persad +6 more
openaire +2 more sources
Cell Death and Disease, 2020 Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade.
Lei Hu +6 more
semanticscholar +1 more source
Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious challenge as a result.
Sarah Saad Hamdan +2 more
doaj +1 more source
Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Klaus Roemer, Kristina Heyne
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Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3 [PDF]
SLAS Discovery, 2006 From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belong to 11 different scaffolds.
Sergei Malarchuk +10 more
openaire +2 more sources
MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin
浙江大学学报. 农业与生命科学版, 2012 To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen +3 more
doaj +1 more source