Results 21 to 30 of about 16,586,228 (338)
Caspase-3, Shears for Synapse Pruning [PDF]
Developmental Cell, 2014 Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced ...
Wen Cheng Xiong +5 more
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Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious challenge as a result.
Sarah Saad Hamdan +2 more
doaj +1 more source
Overexpression of caspase-3 in hepatocellular carcinomas [PDF]
Modern Pathology, 2004 Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra Persad +6 more
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Cell Death and Disease, 2020 Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade.
Lei Hu +6 more
semanticscholar +1 more source
Huntingtin inhibits caspase-3 activation [PDF]
The EMBO Journal, 2006 Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Ioannis Dragatsis +7 more
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Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Klaus Roemer, Kristina Heyne
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Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3 [PDF]
SLAS Discovery, 2006 From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belong to 11 different scaffolds.
Sergei Malarchuk +10 more
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Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the ...
Zhihui Ding +14 more
doaj +1 more source
Characterization of Canine Caspase-3
Journal of Veterinary Medical Science, 2004 The canine caspase-3 gene was cloned and sequenced. The canine caspase-3 cDNA clone was 1473 base pairs in length and encoded 277 amino acids. The predicted amino acid sequence showed 88.4%, 88.0%, 85.9%, 65.9% and 60.6% homology with that of human, pig, mouse, chicken and zebra fish caspase-3, respectively.
Keisuke Oguma +3 more
openaire +4 more sources