Results 21 to 30 of about 471,620 (290)

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. [PDF]

, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Alnemri, Emad S., Aplin, Andrew E., Erkes, Dan A., Fernandes-Alnemri, Teresa, Nardone, Alexandria, Rogers, Corey   +5 more
core   +3 more sources

A non-apoptotic role for caspase-9 in muscle differentiation [PDF]

, 2008
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O, Howley, Breege A, McMahon, Jill M, Mohr, Andrea, Murray, Thomas VA, Ritter, Thomas, Stanley, Alanna, Zwacka, Ralf   +7 more
core   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.

PLoS Pathogens, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert, Georg Malterer, Jean Hausser, Johanna Viiliäinen, Aurélie Fender, Maud Contrant, Tomi Ivacevic, Vladimir Benes, Frédéric Gros, Olivier Voinnet, Mihaela Zavolan, Päivi M Ojala, Juergen G Haas, Sébastien Pfeffer   +13 more
doaj   +1 more source

Intracellular zinc depletion induces caspase activation and p21Waf1/Cip1 cleavage in human epithelial cell lines [PDF]

, 2000
To better understand the mechanisms by which zinc deficiency induces epithelial cell death, studies were done of the effects of intracellular zinc depletion induced by the zinc chelator TPEN on apoptosis-related events in human malignant epithelial cell ...
A. Evdokiou, A. Q. Truong‐Tran, Cui L, F. Chai, G. P. Young, Kolenko V, Krajewska M, Mahadevan I, Medina V, P. D. Zalewski, Shankar AH, Solomons NW, Teare JM, Waga S, Zalewski PD, Zalewski PD   +15 more
core   +1 more source

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium

Indonesian Journal of Cancer, 2007
Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium.
Bambang Dwipoyono
doaj   +1 more source

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]

, 2016
Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis.
A Sangawa, A Wendt, Andrew R. Green, BT Chua, C Berg, C Blanc, C Pop, DE Goll, DM Abd El-Rehim, E Devarajan, EA Rakha, Emad A. Rakha, H Huang, IA Atencio, Ian O. Ellis, J Davis, J Gafni, J Yin, Jy Yoo, L Nakopoulou, LM McShane, M Takamure, M Umar, M Vakkala, MF Rimawi, MH Cardone, MO Hengartner, N Shivapurkar, RL Camp, RN Winter, S Blazquez, S Dutta, Sarah J. Storr, SJ Storr, SJ Storr, SJ Storr, SJ Storr, SJ Storr, SJ Storr, Stewart G. Martin, T Teitz, TM Abdel-Fatah, X Pu, X Zhang, X-H Yang, Xuan Pu, Y Shi, Y Tan, Yimin Zhang, Z Estrov   +49 more
core   +1 more source

An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

Biotechnology Reports, 2015
The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura, Sachio Kunihiro, Yuki Hamashima, Yuki Yoshioka, Shigenobu Tone, Kenji Kameda   +5 more
doaj   +1 more source

The Role of Caspases in Melanoma Pathogenesis

Current Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło, Klaudia Dopytalska, Michał Szczerba, Elżbieta Szymańska, Alicja Petniak, Marcin Kocki, Janusz Kocki, Irena Walecka   +7 more
doaj   +1 more source

Caspase-3 deficiency during development increases vulnerability to hypoxic–ischemic injury through caspase-3-independent pathways

Neurobiology of Disease, 2006
Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West, Madeliene Atzeva, David M. Holtzman   +2 more
doaj   +1 more source

Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells [PDF]

, 2016
Background: Granulosa cell tumors (GCT) are a rare ovarian neoplasm but prognosis is poor following recurrence. Keratin intermediate filaments expressed in these tumors are a diagnostic marker, yet paradoxically, may also constitute a target for ...
Davis, John S., Hou, Xiaoying, Schwab, Nicolette M., Townson, David H., Trisdale, Sarah K.   +4 more
core   +3 more sources