Results 31 to 40 of about 476,553 (353)

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.

PLoS Pathogens, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert, Georg Malterer, Jean Hausser, Johanna Viiliäinen, Aurélie Fender, Maud Contrant, Tomi Ivacevic, Vladimir Benes, Frédéric Gros, Olivier Voinnet, Mihaela Zavolan, Päivi M Ojala, Juergen G Haas, Sébastien Pfeffer   +13 more
doaj   +1 more source

Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells [PDF]

, 2016
Background: Granulosa cell tumors (GCT) are a rare ovarian neoplasm but prognosis is poor following recurrence. Keratin intermediate filaments expressed in these tumors are a diagnostic marker, yet paradoxically, may also constitute a target for ...
Davis, John S., Hou, Xiaoying, Schwab, Nicolette M., Townson, David H., Trisdale, Sarah K.   +4 more
core   +3 more sources

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival [PDF]

Apoptosis, 2016
Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought to investigate the prognostic potential of caspase-3 and -8 in breast cancer, as well as the prognostic
Xuan, Pu, Storr, Sarah J., Zhang, Yimin, Rakha, Emad, Green, Andrew R., Ellis, Ian O., Martin, Stewart G.   +6 more
openaire   +4 more sources

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium

Indonesian Journal of Cancer, 2007
Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium.
Bambang Dwipoyono
doaj   +1 more source

Canalization of the Vestibular Plate in the Absence of Urethral Fusion Characterizes Development of the Human Clitoris: The Single Zipper Hypothesis. [PDF]

, 2016
PurposeWe characterized the early gestation development of the female external genitalia using optical projection tomography to visualize anatomical structures at high resolution.Materials and methodsFirst and early second trimester human female fetal ...
Baskin, Laurence, Botta, Sisir, Cao, Mei, Cunha, Gerald, Li, Yi, Overland, Maya, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +8 more
core   +2 more sources

An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells

Biotechnology Reports, 2015
The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura, Sachio Kunihiro, Yuki Hamashima, Yuki Yoshioka, Shigenobu Tone, Kenji Kameda   +5 more
doaj   +1 more source

The Role of Caspases in Melanoma Pathogenesis

Current Issues in Molecular Biology
Melanoma (malignant melanoma, MM) is an aggressive malignant skin cancer with an increasing incidence rate. The complete pathogenesis of MM in not clear.
Agnieszka Szmurło, Klaudia Dopytalska, Michał Szczerba, Elżbieta Szymańska, Alicja Petniak, Marcin Kocki, Janusz Kocki, Irena Walecka   +7 more
doaj   +1 more source

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long‐chain fatty acid oxidation disorders

Physiological Reports, 2019
Excessive cellular accumulation or exposure to lipids such as long‐chain acylcarnitines (LCACs), ceramides, and others is implicated in cell stress and inflammation.
Colin S. McCoin, Melanie B. Gillingham, Trina A. Knotts, Jerry Vockley, Kikumi D. Ono‐Moore, Michael L. Blackburn, Jennifer E. Norman, Sean H. Adams   +7 more
doaj   +1 more source

Caspase-3 deficiency during development increases vulnerability to hypoxic–ischemic injury through caspase-3-independent pathways

Neurobiology of Disease, 2006
Neonatal hypoxia–ischemia (H–I) is a common cause of perinatal morbidity and mortality leading to prominent activation of caspase-3 in the brain. Previous studies have shown that acute inhibition of caspase-3 can protect against neonatal H–I in rats.
Tim West, Madeliene Atzeva, David M. Holtzman   +2 more
doaj   +1 more source

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +1 more source