Results 21 to 30 of about 18,682,677 (305)
Caspase-3-Responsive Fluorescent/Photoacoustic Imaging of Tumor Apoptosis
, 2023 Caspase-3 is an essential executor in apoptosis, and its activation has been regarded as a biomarker of cell apoptosis. The development of Caspase-3-responsive multimodal probes is a promising research prospect.
Jiajun Liu (692586) +11 more
core +1 more source
Huntingtin inhibits caspase‐3 activation [PDF]
The EMBO Journal, 2006 Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Yu, Zhang +7 more
openaire +2 more sources
Tau and Caspase 3 as Targets for Neuroprotection [PDF]
International Journal of Alzheimer's Disease, 2012 The peptide drug candidate NAP (davunetide) has demonstrated protective effects in variousin vivoandin vitromodels of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases
Idan-Feldman, Anat +2 more
openaire +2 more sources
Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Kristina, Heyne, Klaus, Roemer
openaire +2 more sources
Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]
, 2003 Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B. +9 more
core +1 more source
Characterization of Canine Caspase-3
Journal of Veterinary Medical Science, 2004 The canine caspase-3 gene was cloned and sequenced. The canine caspase-3 cDNA clone was 1473 base pairs in length and encoded 277 amino acids. The predicted amino acid sequence showed 88.4%, 88.0%, 85.9%, 65.9% and 60.6% homology with that of human, pig, mouse, chicken and zebra fish caspase-3, respectively.
SANO, Junichi +3 more
openaire +3 more sources
Overexpression of caspase-3 in hepatocellular carcinomas [PDF]
Modern Pathology, 2004 Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra, Persad +6 more
openaire +2 more sources
Caspase-3, Shears for Synapse Pruning [PDF]
Developmental Cell, 2014 Motor neurons regulate neuromuscular junction formation by using agrin to stimulate acetylcholine receptor clustering and using acetylcholine to disperse unnecessary receptor clusters on muscle fibers. Wang et al. (2014) now report in this issue of Developmental Cell a critical role for caspase-3 in intracellular mechanisms of acetylcholine-induced ...
Shen, Chengyong +2 more
openaire +2 more sources
Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3 [PDF]
SLAS Discovery, 2006 From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belong to 11 different scaffolds.
Ilya, Okun +10 more
openaire +2 more sources