Results 31 to 40 of about 16,586,228 (338)
Bacterial secreted effectors and caspase‐3 interactions [PDF]
Cellular Microbiology, 2014 Apoptosis is a critical process that intrinsically links organism survival to its ability to induce controlled death. Thus, functional apoptosis allows organisms to remove perceived threats to their survival by targeting those cells that it determines pose a direct risk.
Wall, Daniel M., McCormick, Beth A.
openaire +4 more sources
Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source
Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 Cleavage of Rho associated Coiled Coil kinase I (ROCK I) by caspase-3 contributes to membrane blebbing. Whether caspase-3 and ROCK I also play a role in the release of membrane vesicles is unknown. Therefore, we transfected a human breast cancer cell line (MCF-7) that is caspase-3 deficient, lacks membrane blebbing, and does not release membrane ...
Eric Reits +8 more
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Nature Communications, 2019 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Corey Rogers +5 more
semanticscholar +1 more source
Controlling TRAIL-mediated caspase-3 activation [PDF]
Leukemia, 2004 This commentary is addressed at the paper by Dr Jie and his co-workers in the current issue of Leukemia (‘Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells’). In this paper, the authors show the preferential use of Bax over Bak for the induction of mitochondrial apoptotic events in leukemic cell exposed to TRAIL 1.
Micheau, Olivier, Mérino, Delphine
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Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.
PLoS Pathogens, 2011 Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Guillaume Suffert +13 more
doaj +1 more source
Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
Cell Death and Disease, 2019 Pyroptosis, a form of programmed cell death (PCD), has garnered increasing attention as it relates to innate immunity and diseases. However, the involvement of pyroptosis in the mechanism by which lobaplatin acts against colorectal cancer (CRC) is ...
Junhui Yu +8 more
semanticscholar +1 more source
Caspase-3 promotes genetic instability and carcinogenesis. [PDF]
Molecular Cell, 2015 Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis.
Xinjian Liu +6 more
semanticscholar +4 more sources
Structural Basis for the Inhibition of Caspase-3 by XIAP [PDF]
Cell, 2001 The molecular mechanism(s) that regulate apoptosis by caspase inhibition remain poorly understood. The main endogenous inhibitors are members of the IAP family and are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and -7.
Stephen W. Fesik +7 more
openaire +3 more sources
Nature Communications, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Corey Rogers +5 more
semanticscholar +1 more source