Results 191 to 200 of about 11,510,202 (303)

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

TGF beta RII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder

, 2007
Aim: The aim of this study was to determine the potential synchronous contribution of alterations in TGF-beta RII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLH1/hMSH2 expression.
Saetta, Angelica A., Korkolopoulou, Penelope, Karlou, Maria, Levidou, Georgia, Goudopoulou, Athina, Thymara, Irene, Stamatelli, Angeliki, Tzivras, Michalis, Michalopoulos, Nikolaos, V., Thomas-Tsagli, Euphemia, Patsouris, Efstratios   +11 more
openaire   +1 more source

NLRP3/Caspase-1 Regulate Macrophage Efferocytosis by Modulating ADAM17-Mediated MerTK Cleavage in Liver Ischemia-Reperfusion Injury. [PDF]

Research (Wash D C)
Guan G, Yu C, Miao L, Xiong T, Sun Y, Jin X, Zhao P, Lu Y, Wang L, Chen P, Di G.   +10 more
europepmc   +1 more source

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

Innate Immunity, 2017
Mark A. Wacker, Athmane Teghanemt, J. Weiss, Jason H. Barker   +3 more
semanticscholar   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Caspase-2 inhibits mitochondrial respiration in colorectal adenocarcinoma cells. [PDF]

Cell Commun Signal
Sillapachaiyaporn C, Yapryntseva MA, Mamedova AR, Abdelghany L, Gogvadze V, Zhivotovsky B.   +5 more
europepmc   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

Proceedings of the National Academy of Sciences of the United States of America, 2015
Cierra N. Casson, Janet M Yu, V. M. Reyes, F. Taschuk, Anjana Yadav, Alan M. Copenhaver, H. Nguyen, R. Collman, Sunny Shin   +8 more
semanticscholar   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Japanese encephalitis virus activates the NLRP3/caspase-1/GSDMD signaling pathway in dopaminergic neurons. [PDF]

PLoS Negl Trop Dis
Guo X, Lu S, Huang Z, Li J, Cheng G, Hu X, Zhang W, Gu C.   +7 more
europepmc   +1 more source